腾盛博药-B2025年度报告

Brii Biosciences Limited騰盛博藥生物科技有限公司 ()於開曼群島註冊成立的有限公司 股份代號 :2137 2025年度報告 23567213062778284868890156 騰盛博藥騰盛博藥 HBVHBVBRII-179elebsiran2bENSUREENRICHENHANCE 2bHBV2bENSURE4242025AASLD®BRII-179ENSURE4ENHANCE2025PEG-IFNα2bENRICHENHANCE2026 2024BrianJohns 202512OpenBench 2 0 2 57soralimixinHBVHIV HBV Zhi HONG Gregg Huber ALTONMartin J MURPHY JRGrace Hui TANG Edwin Kwok & Co Grace Hui TANG Maples and Calder (Hong Kong) LLP Martin J MURPHY JRGrace Hui TANG • Gregg Huber ALTONZhi HONGMartin J MURPHY JRGrace Hui TANG PO Box 309, Ugland HouseGrand Cayman KY1–1104Cayman Islands Gregg Huber ALTON 1617 173100192 First Citizens BankGoldman Sachs International BankJ.P. Morgan Chase Bank WeWork One City CenterSuite 05-110, 110 N Corcoran StDurham, NC 27701United States of America 33191920 www.briibio.com 2137 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary HallCricket SquareGrand Cayman KY1-1104Cayman Islands 2021713 2025HBV 2025HBV20252bENRICHENHANCE2026 H B V2 0 2 57soralimixinsoralimixinMDRHBV AI 202520252026我們 HBV 騰盛博藥 2025HBV2bENSURE2bENRICHENHANCE(NatureMedicine)ENSUREelebsiranBRII-179HBsAgENHANCE 2025ADME/DMPKCMC 202512OpenBench 騰盛博藥HBV HBVHBV (1)騰盛博藥VirBiotechnologyelebsirantobevibart (2)VirBiotechnologyHDVelebsirantobevibart3 (3)SoralimixinBRII-693 (4)騰盛博藥soralimixin騰盛博藥soralimixin HBV 2bHBV2bENSURE OpenBenchAI soralimixin HBVHIV HBV HBV 2bENSUREENRICHENHANCEHBVelebsiranHBVsiRNABRII-179HBV BRII-179 BRII-179HBVPre-S1Pre-S2SHBVBTBRII-179 BRII-1792bENSURE2bENRICHENHANCEBRII-179HBV 2bENSURE1-3PEG-IFNαelebsiranPEG-IFNα4BRII-179HBsAg •2025ENSURE4BRII-179(AASLD)®BRII-179 BRII-179-HBsHBsAg(520[34-2,165]IU/mL)(185 [51-672] IU/mL) EOT24BRII-179-HBsHBsAg42.1% (8/19)8.3% (1/12) HBsAgENSUREHBsAg1,500IU/mL50% (4/8)-HBsHBsAg1,5143,086 IU/mLBRII-179HBsAg-HBs ENSURE2026 •BRII-179HBV2bBRII-179 ENRICHBRII-179HBV ENHANCEBRII-179elebsiranPEG-IFNαENSURE4PEG-IFNα24 ENRICHENHANCE2026 •CDE3ENRICHENHANCE ElebsiranTobevibart ElebsiranAlnylamPharmaceuticals,Inc.HBVsiRNAHBVRNAHBVHDVElebsiranHBV2020VirBiotechnologyelebsiran TobevibartHBsAgHBVHDVTobevibartVirBiotechnologyFcHBsAgXencorXtend™Tobevibart2022Vir Biotechnologytobevibart •202552025EASLENSURE1-324PEG-IFNαelebsiranPEG-IFNα •ENSURE1-3PEG-IFNαsiRNA(elebsiran)PEG-IFNαelebsiranHBV •VirBiotechnologytobevibartelebsiranCHDECLIPSEECLIPSE1ECLIPSE3VirBiotechnology2026ECLIPSE12027ECLIPSE 2ECLIPSE 3 SoralimixinBRII-693MDRsoralimixinSoralimixinMDR •20257soralimixinsoralimixin •FDAsoralimixinFDA HIV HIV •BRII-753NRTTIEFdANCEBRII-753HIV •BRII-732NCEEFdAHIVEFdANRTTIHIVBRII-7321HIV 2025騰盛博藥 202512OpenBench 2026 20252026 20251231212.9 HBV ENRICHENHANCE2026HBV 20251231 1. 2024123118.62025123118.6 2. 20241231141.472.62025123168.835.633.0 3. 20241231197.72025123114.8212.5 4. 202412317.97.920251231202488 5. 20241231249.836.920251231212.9HBV21.016.2 6. 20241231153.243.720251231109.524.810.4 7. 20251231202412312,413.41,941.0BRII-179 8. 9. (1) (2)100% 10. 20251231 20251231 20251231168.9 11. 2025123120251231 12. 2025123120241231 13. 2025123155.4%28.2%16.2%0.2% 14. 202512317520251231 20252026 202512311532024123119421% 15. 16. 20251231 PFIC 2025123120251231PFICPFIC 20251231PFICPFIC2024322 ZhiHONG6220183220213242018223202291202171320229120217132022930Hong20181Brii Biosciences, Inc2019220185201811BriiBiosciences Offshore Limited Hong25GlaxoSmithKlineplc.GSKGSK2007420183ViiVHealthcare LimitedViiVGSKHIV20091020183HIV20061220073ArdeaBiosciences,Inc.2000620073BauschHealth Companies Inc.Valeant Pharmaceuticals InternationalBHC Hong1985719921 4820229302022916202511182021482020912025111820223222025111820218202172021620233Brii Biosciences Pty Ltd. TernsPharmaceuticals,Inc.TERN20196202082018120196201692017122014820169Ropes&Gray LLP2012920148Davis Polk & Wardwell LLP2007920099Salk Institute for Biological Studies 1999720021020076201262013120168 MartinJ MURPHY JR832021713Murphy Jr20217132021713202291 Murphy Jr20033AlphaMed Consulting, Inc.MurphyJr2000820201(CEORoundtable on Cancer)201911(LifeSciences Consortium)(CEORoundtableon Cancer)•(CharlesA.Sanders Life Sciences Award)MurphyJr202112013(American Society of Clinical Oncology) MurphyJr196721969620097(Queen’s University of Belfast) GraceHui TANG6620216222021713Tang2021713202563Tang Tang20237Pirelli&C.S.p.APIRC202279999NTESESG20213ECARX Holdings IncECX20214ElkemASAOsloELKTang2020720243Textainer Group Holdings LimitedTGH20189MBA20229 1990320206Tang Tang1982619846Tang199312Tang1995720033 762021622202171320217132021713202291 4051720042543200711255220189200612MLCO200083492010122120064 28832009620156238020043201612102201132018961362013102019462020151220205201212202011MelcoResortsand Entertainment(Philippines)CorporationMRP2008120262ATACreativityGlobalAACG 2003112017220014200611200112200412200172002619941199722000820003200081989119805198812CLP PowerHongKong Limited219761019795ArthurAndersen & Co. 19981120149 197561976819938• Gre