第1次会议-粮农组织世界卫生组织食品添加剂联合专家委员会

SUMMARY AND CONCLUSIONSIssued on4July2025 The One-hundredth meeting of the Joint FAO/WHO Expert Committee on Food Additives was held in Romefrom 10 to 19 June 2025. The purpose of the meeting was to evaluate the safety of certain food additives. Thepresent meeting was the One-hundredth in a series of similar meetings. The tasks before the Committee wereto (a) further elaborate principles governing the evaluation of food additives; (b) undertake safety evaluationsof certain food additives; and (c) review and prepare specifications for certain food additives. Dr R. Cantrill served as Chairperson and Dr D. Bedford served as Vice-chairperson. Ms A. Vlachou andMr K. Petersen served as joint secretaries. The Committee evaluated the safety of eight food additives and one processing aid and revised thespecifications of one food additive and six processing aids. The report of the meeting will be published as WHO Technical Report Series No. 1058. The report willsummarize the main conclusions of the Committee in terms of acceptable daily intakes (ADIs) and othertoxicological, dietary exposure and safety recommendations. Information on deliberations and conclusionswith regards to the specifications for the identity and purity of certain food additives examined by theCommittee will also be included. The participants are listed in Annex 1. Information of a general nature that the Committee wishes todisseminate quickly is provided in Annex 2. Future work and recommendations arising from the summaryreport of the One-hundredth meeting are summarized in Annex 3. Finally, Annex 4 includes requests forcorrections that were reported to the JECFA Secretariat, evaluated by the Committee and found to benecessary (note that these corrections will only be made in the electronic versions available in the onlinedatabase). Toxicological monographs summarizing the data that were considered by the Committee inestablishing ADIs will be published as WHO Food Additives Series No. 91. New and revised specifications forthe identity and purity of the compounds will be published in FAO JECFA Monographs No. 35. More information on the work of JECFA is available at: http://www.fao.org/food-safety/scientific-advice/jecfa/en/ and https://www.who.int/foodsafety/en/. The issuance of this document does not constitute formal publication. The document may, however,befreelyreviewed,abstracted,reproducedortranslated,inwholeorinpart,butnotforsaleoruseinconjunctionwithcommercialpurposes. The Committee withdrew the previously established ADI of 0–1.25mg/kg bw for ascorbyl palmitateor ascorbyl stearate, or the sum of both. The Committee noted that the previous ADI for ascorbyl palmitateor ascorbyl stearate, or the sum of both, was based on toxicological data for ascorbyl palmitate, andtherefore established a group ADI “not specified”bfor ascorbyl palmitate or ascorbyl stearate, or the sumof both. The Committee previously assigned an ADI “not specified”bto carob bean gum. However, an ADI does notapply to infants younger than 12 weeks since they might be at risk at lower levels of exposure comparedwith older age groups. To complete the evaluation, the Committee therefore requested studies in neonatalanimals adequate for the evaluation of the safety of carob bean gum in infant formula. Newly submittedunpublished data obtained from a neonatal pig study evaluated at the present meeting allowed theCommittee to identify a NOAEL of 2400mg/kg bw per day, the highest dose tested. Based on the estimated high dietary exposures for infants, the Committee noted that MOEs calculatedfor the use of carob bean gum at 1000 mg/L and 6000 mg/L in infant formula were 9 and 1.5, respectively.The MOE for the high exposure calculated for infants from the use of carob bean gum at 10 000 mg/L ininfant formula was less than 1. The Committee concluded that the MOEs based on carob bean gum concentrations of 1000 and6000 mg/L in infant formula indicate a low risk;however, the MOE based on a concentration of 10 000 mg/Lindicates a potential risk.Based on the available data and considering the short exposure period involved,the Committee concluded that there is no concern for the disruption of the intestinal microbiota by carobbean gum used as a thickener in infant formula. At its Forty-fourth meeting in 1995, the Committee established an ADI of 0–0.1 mg/kg bw for DSS. The high(P95) dietary exposure estimates of DSS of up to0.30 mg/kg bw per day for children aged 1–17 years couldexceed this ADI. The estimates for adults were all below the ADI. Considering that (i) the dietary exposure estimates are conservative because of the assumptions thatall soft drinks thatcould contain DSS do contain this food additive (although other food additives thatperform the same function in foods are available) and, when DSS is used, it will always be present at themaximum and/or average use levels; and (ii) the ranges of exposureestimates based on only maximum uselevels were comparable to those b