The healthcare supply chain faces significant challenges, including vulnerabilities and a resilience gap, as revealed by the COVID-19 pandemic. The industry must shift to a more optimized supply chain to better prepare for future unpredictability. An aging society, increasing rates of chronic disease, and eroding margins place additional strain on the traditional care model, making it more urgent to address supply chain challenges. Forward-looking organizations must constantly apply lessons learned to better prepare for the future and improve efficiency and clinical outcomes.