华领医药-B年报 2023
(於開曼群島註冊成立的股份有限公司 )股份代號 :2552 2023年報 2 4 7 9 22 30 59 76 81 82 84 85 87 156 158 20241 1 Robert Taylor NELSEN Robert Taylor NELSENFangxin LI202310 12 William Robert KELLER • William Robert KELLER 309KY1-1104 William Robert KELLERFangxin LI202310 12 362201203 Robert Taylor NELSENWilliam Robert KELLER 362202 Maples Fund Services (Cayman) Limited1093KY1-1102 1617 1 232 277 www.huamedicine.com 2552 •華堂寧®220241 15.3910.78•華堂寧®800202312311,461202210202312 3194.2•2022214.6%131•dorzagliatin2024dorzagliatin20232024400•72華堂寧®•20,0002華堂寧®14dorzagliatinβ2•dorzagliatin •dorzagliatin(GK)GLP-1dorzagliatinGLP-120233dorzagliatinGLP-120236(ADA)dorzagliatinGoto-Kakizaki •20236SEED-DREAM52DREAMSEEDdorzagliatinSEEDβ2TIR •GLP-1IND2023dorzagliatin(DPP-4)(SGLT-2)dorzagliatinDPP-4SGLT-2β •dorzagliatin(CUHK)SENSITIZEII(IGT)(NGT)IGT25IGTIGTDorzagliatinIGTNGT •Glucokinase(NAM)mGLUR5 NAM •202312 311,460.8•202312 3176.6251,000華堂寧®•202312 31130.665.1 •202312 31383.3171.5•202312 3142.032%171.5•202312 317.74%211.2•202312 318.14%211.5 2021華堂寧®2022(ATC)20237華堂寧®202312華堂寧®46%10.78(NHSA)華堂寧®華堂寧®2 dorzagliatin2024dorzagliatin20232024400 72華堂寧® 20,0002華堂寧®14dorzagliatinβ2 GKA GLP-1GKAGKA IND2024GKA dorzagliationdorzagliationGLP-1RA Robert Nelsen 華堂寧®2024 1 15.3910.7822華堂寧®90% 華堂寧®800202312 311,461 202210202312 3194.2 2022214.6%131 dorzagliatin2024dorzagliatin20232024400 72華堂寧® 20,0002華堂寧®14dorzagliatinβ2 dorzagliatin dorzagliatin(GK)GLP-1dorzagliatinGLP-120233dorzagliatinGLP-120236(ADA)dorzagliatinGoto-Kakizaki 20236SEED-DREAM52DREAMSEEDdorzagliatinSEEDβ2TIR GLP-1IND2023dorzagliatin(DPP-4)(SGLT-2)dorzagliatinDPP-4SGLT-2β dorzagliatin(CUHK)SENSITIZE II(IGT)(NGT)IGT25IGTIGTDorzagliatinIGTNGT Glucokinase(NAM)mGLUR5 NAM 18A.08(3) (GK)dorzagliatinβ(TIR)JulianaChanDorzagliatin(DPP-4)(SGLT-2)2DorzagliatinGLP-1β1dorzagliatin dorzagliatin(GK)(CHI)GK(NAM)(GKA) 華堂寧®dorzagliatindorzagliatindorzagliatinGLP-1GKAI(GK NAM)NAM(mGLUR NAM)(FID) 華堂寧®華堂寧®β2 202312 31251,000華堂寧®76.6202210202212 3153,000華堂寧®17.6 2023華堂寧®(NHSA)2華堂寧® 202312 3137.448.8%202212 3143.7%5.1% dorzagliatin202212 3141.589.1202312 31130.654.322.512.3 2022123126.021.9202312 314.1202312 31202212 31 10,476,00094,280,0002,980,500 202212 31129.95.8202312 31124.1i5.6ii)3.7202312 31NDAiii1.5 202312 317.9202212 313.72023 202312 3179.834.529.715.6 202212 31129.542.0202312 31171.5 •dorzagliatin202212 314.93.4202312 318.32023dorzagliatin2 •dorzagliatin202212 314.411.82023123116.22023 •(CMC)202212 319.843.9202312 3153.720232022NDA •202212 3184.322.3202312 3162.0 •202212 3123.74.1202312 3127.82023 202312 31202212 31 202312 31202312 31889.4202312 311,460.8 202312 31202312 315% 1.202312 31 2022202312 31 202312 31889.4211.230.41,131.020231231202312 31 202212 31230.1203.50.527.120221231202212 31 202312 318.1202212 314.8 202212 3169.1202212 3121.5 20221231751.9202312311,320.4202212 31940.3202312 311,572.5華堂寧®800.0 2023202212 31167.897.6 202312 31 5%5%5%5%5% (8,233)(9,893)(2,316)(2,250) 2023202212 311,320.4751.9 ¹23 1. 2. 3. 202312 31202212 311.2202312 31202212311.1華堂寧®800.0202312 31202212 31130.9% 202312 313.6 1,565,00020221,565,0002.75%101,565,00020221,565,0002.75%10 202312 31dorzagliatin 202312 31 6120106 4201851120106 420108201132020420212202212 30dorzagliatin2011dorzagliatin1992dorzagliatin 1982719851119928385820079201092001SAPA 20142020104144202010 30 5320185 11201712 2220233 30201712 22202333020184 24192013620171220007201351995919997420201120236202112 232185 1992619956199512 4920241 120184202082021112013220101999122010101997619996200462009NIH2015(Nature Genetics, Lancet Diabetes Endocrinol, Circulation: Cardiovascular Genetics)603 Robert Taylor NELSEN6020104 2320185 1120108 1994NelsenARCHVenture Partners30Nelsen20186213720199PRIMEMedicine202210PRME20189SanaBiotechnologySANA20188LyellImmunopharmLYEL20171Vir Biotechnology Inc.VIR2021320224Renovation Healthcare Acquisition Corp.REVH20158201810SiennaBiopharmaceuticals,Inc.SNNA2012820186SyrosPharmaceuticals,Inc.SYRS2013820183JunoTherapeutics,Inc.JUNO20061201412KYTHERABiopharmaceuticals,Inc.KYTH20071220176AgiosPharmaceuticals Inc.AGIO2013920163SageTherapeutics,Inc.SAGE20142201511BellerophonTherapeutics,Inc.BLPH19941120045AdolorCorporationADLR1998620068Illumina,Inc.ILMN2007920146FateTherapeutics,Inc.FATE2000720137NeurogesX,Inc.NGSX201111202012UnityBiotechnology,Inc.UBX2018820216KarunaTherapeutics Inc.KRTX2017620216BeamTherapeuticsInc.BEAM2015520226DenaliTherapeutics,Inc.DNLI20126 29NGSX(OTC)Nelsen Nelsen19851987 FangxinLI31202310 12202310 12 Li202142359WuXi AppTec Singapore Pte. Ltd.20194202012Bain&Company2016820191HAIKUI Regenerative Medicine Li2014620189 William Robert KELLER7520188 2620189 14Keller 20175Keller226920208SS688065.S SK e l l e r202138A r t i s a nAcquisitionCorp.ARTA2010122020104144202010 3020149201512Keller19742003KellerKellerAlexionPharmaceuticals,Inc.ALXN20091220155NKBP20088201112HBM Biomed China Partners 19727Keller 7420188
