北海康成製藥有限公司2025年年报

CANbridge Pharmaceuticals Inc.北 海 康 成 製 藥 有 限 公 司 Incorporated in the Cayman Islands with limited liability 年報2025 26810112530718994959798100 A FDA 20211210 2022624 202111182024627 202111182024627 2019201972520192021611 89 Nexus WayCamana BayGrand CaymanKY1-9009Cayman Islands 20256302025827Fangxin Li2025625 Ogier Global (Cayman) Limited89 Nexus WayCamana BayGrand CaymanKY1-9009Cayman Islands Richard James GregoryJames Arthur Geraghty 183171712-1716 38821109 24840 11 2026330 20263302026330 1228 1131 James Arthur GeraghtyRichard James Gregory Richard James Gregory2025630Fangxin Li2025625 www.canbridgepharma.com James Arthur Geraghty20256302025827Richard James Gregory2025630 •2024123185.135.141.2%2025123150.020212024®®®20249.022.0%2025® •115.2202412 315.520251231109.7101.020252242025228202412312025123197.73.3 •20241231251.8206.782.1%2025123145.1®2025 •2024123168.231.446.0%2025123136.8 •2024123174.927.536.7%202512 3147.420242025® •457.420241231442.6202512 3114.814.8 •20241231347.0266.576.8%2025123180.414.820241231442.6 20251231 8Hunterase®®®®Hunterase®® ® 2026330 201220251231731 2025123141(CHARD) 2012 MPS II(LSD)AALGS(PFIC) •20209®(CAN101)MPS II •2023®ALGS•2024®ALGSPFIC®ALGS•20236PNHCAN106 1bLDH •20255®IIII1 •202512® 202411ScriptrStitchR™ RNAFICBIC 20243,00020324,000www.fiercepharma.com 2018121202386207 20251 172025 80% 20258(i)®®®50(ii)74,971,46814.99%100 2026 ®IIIIWuXi Biologics 74 20211210 ®CAN101 •®MPS IIERTERT® •20209®MPS II®GC Pharma101/2Elaprase®®MPS IIIII® •20215®20251231893202512 311426.26 • ®CAN108 •®IBATALGSFDAPFIC®1,700®ALGSPFIC200Mirum Pharmaceuticals, Inc.MirumALGS2b118®Mirum®PFIC393PFIC1PFIC2PFIC3 PFIC4 PFIC6PFIC3®z •Mirum® •202412 31®ALGSPFIC®ALGS •20245® •202412®PFIC •202412®ALGS •20241®20251231900ALGS20251231532.6 ®CAN103 •®GDERT•®ERT•20231GD IIII®1/2GDGD III2269.HK®ERTIIIIGD•20253®GMP®•20255®IIII1•202512®•® CAN106 •CAN106C5PNHMGCAN106PK/PDCAN106PNHC5 •20192020WuXi Biologics Ireland LimitedPrivus Biologics, LLCPNHC5CAN106 •CAN106FDAMGCAN10650%MG7 •20236CAN106PNH1bCAN10624C53C50.5CAN106CAN106PNH •C5CAN106PNH •CAN106CAN106 •202411ScriptrStitchR™ RNA •20251231DMD 20253®GMP® GC PharmaMirumCDMO 20258®®®2025®® (KOL) 20263 10WuXi Biologics HealthCare Venture84,033,6132.3820262162026310 2024123185.135.141.2%2025123150.020212024®®®20249.022.0%2025 2024123130.818.12025123112.7 2024123154.317.02025123137.32025123174.7%2024123163.8% 115.2202412315.5202512 31109.7101.020252242025228202412312025123197.73.3 2024123174.927.536.7%2025123147.420242025® 2024123168.231.446.0%2025123136.8 20241231251.8206.782.1%2025123145.1®2025 202412318.6202512312.2 2025123166.63.558.94.00.2202412 3110.5 20251231 2025123115.0202412 3130.43.4%3.8% 202512 3124.2%2024 12 319.4% 202512319.1%2024123126.0% 20251231 20251231202512316,000 20251231 20251231 201972520192021611 54,549,23055,708,000 510,0007,433,6232025123121,653,760 2021111820246 27 202462710%10% 20246 2712,136,000 581,4001,631,600202512314,581,750 202111182024627 202462710%10% 20246 2724,685,000 804,2505,772,421202512318,749,500 56201812021621 25Kosan Biosciences, Inc.19985200082002(Genzyme Corporation)201120126Tullis Health Investors 2016520178Termeer 19927199741998420025 462025630 20019200842006220064200852014112019320202561114062022316202310122552 20017201311 482025827 (GBI)20164202112 2011 James Arthur Geraghty712018718Geraghty Geraghty3320135201612GeraghtyThirdRock VenturesGeraghty20114201212SanofiS.A.Geraghty1992201119932007GeraghtyGenzyme Transgenics CorporationGeraghtyGeraghty2018520241201711202412Orchard TherapeuticsORTXPieris PharmaceuticalsPIRSGeraghty201610201412013720233Fulcrum TherapeuticsFULCVoyager TherapeuticsVYGRAceragen, Inc.ACGNIdera PharmaceuticalsIDRA Geraghty19805 Richard James Gregory6820204Gregory Gregory33GregoryHomology MedicinesFIXXProMIS NeurosciencesPMN202362015120198GregoryImmunoGen Inc.19892GregoryGENZ25Genzyme Sanofi1990Canji, Inc.1989Gregory(WorcesterFoundation for Experimental Biology) Gregory1980619861Gregory20102(American Institute for Medicaland Biological Engineering) 622021611 28201922024111902202162279202142561202482126 2017102019509072012120179 20111201111CIG20067201112005320066200082004122009121401994520008BNP Prime Peregrine Capital Limited 1989519981119921119937 572022216 222002820043JP Morgan Chase Bank2004620131213 199320002002 Fangxin Li322024930Li2025625 2021420256Li6032592359WuXi AppTec Singapore Pte. Ltd.Li20231020256255220194202012Bain & Company2016820191HAIKUI Regenerative Medicine Li2014620189 56201812021621Glenn Hassan20249 Gerald Cox6720197 20162018CoxCambridgeEditas Medicine20082016CoxCambridgeCerdelga®Xenpozyme®Hectoral®Cerezyme®Aldurazyme®Elaprase®Cox Cox1989199719801989 2025123138202512316 202512 31202512 31 94 20251231(2024 202112108 14 26 9737 202512312024 202512 3120251231 2021121056,251,00012.182021129 20258 1274,971,4681.34 1.34a20258111.6719.76%(b)202581