TriSalus Life Sciences Inc美股招股说明书(2026年2月26日版)

TriSalus Life Sciences, Inc. We are offering 9,756,100 shares of our common stock, par value $0.0001 per share (“Common Stock”), in this offering. Our Common Stock is listed on The Nasdaq Global Market under the symbol “TLSI.” On February 18, 2026, the last reported saleprice of our Common Stock on The Nasdaq Global Market was $4.64 per share. We are a “smaller reporting company” under the federal securities laws and, as such, have elected to comply with certain reducedreporting requirements for this prospectus and may elect to do so in future filings. Investing in our Common Stock involves a high degree of risk. See “Risk Factors” beginning on page S-4 of this prospectussupplement and in the documents incorporated by reference into this prospectus supplement before making your investmentdecision. Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of thesesecurities or passed upon the adequacy or accuracy of this prospectus supplement or the accompanying prospectus. Anyrepresentation to the contrary is a criminal offense. (1)See “Underwriting” beginning on page S-9 for additional disclosure regarding the compensation to be received by the underwriter. We have granted a 30-day option to the underwriters to purchase up to 1,463,415 additional shares of Common Stock solely to coverover-allotments, if any. The underwriters expect to deliver the shares to purchasers on or about February 23, 2026. Sole Book-Runner Lake Street Prospectus supplement dated February 19, 2026 Prospectus Supplement ABOUT THIS PROSPECTUS SUPPLEMENT This prospectus supplement and the accompanying prospectus relate to an offering of our Common Stock. Before buying anyshares of the Common Stock that we are offering, we urge you to carefully read this prospectus supplement and the accompanyingprospectus, together with the information incorporated by reference as described under the headings “Where You Can Find More This document is in two parts. The first part is this prospectus supplement, which describes the terms of this offering ofCommon Stock and also adds to, updates and changes information contained in the accompanying prospectus and the documentsincorporated by reference. The second part is the accompanying prospectus, which provides more general information, some of whichmay not apply to this offering. Generally, when we refer to this prospectus, we are referring to both parts of this document combined,together with the documents incorporated by reference herein and therein. To the extent the information contained in this prospectussupplement differs from or conflicts with the information contained in the accompanying prospectus or any document incorporated byreference having an earlier date, the information in this prospectus supplement will control. If any statement in one of these documentsis inconsistent with a statement in another document having a later date—for example, a document incorporated by reference into this You should assume that the information contained in this prospectus supplement is accurate as of the date on the front coverof this prospectus supplement only and that any information we have incorporated by reference or included in the accompanyingprospectus is accurate only as of the date given in the document incorporated by reference or as of the date of the accompanyingprospectus, as applicable, regardless of the time of delivery of this prospectus supplement, the accompanying prospectus, any relatedfree writing prospectus, or any sale of our Common Stock. Our business, financial condition, results of operations and prospects mayhave changed since those dates. We further note that the representations, warranties and covenants made by us in any agreement that is This prospectus supplement and the accompanying prospectus contain summaries of certain provisions contained in some ofthe documents described herein, but reference is made to the actual documents for complete information. All of the summaries arequalified in their entirety by the actual documents. Copies of some of the documents referred to herein have been or will be filed asexhibits to the registration statement of which this prospectus is a part or as exhibits to documents incorporated by reference herein,and you may obtain copies of those documents as described below under the headings “Where You Can Find More Information” and“Information Incorporated by Reference.” We further note that the representations, warranties and covenants made by us in any This prospectus supplement and the accompanying prospectus do not constitute an offer to sell, or a solicitation of an offer topurchase, the securities offered by this prospectus supplement and the accompanying prospectus in any jurisdiction to or from anyperson to whom or from whom it is unlawful to make such offer or solicitation of an offer in such jurisdiction. Persons into whose This prospectus supplement and the accom