方达控股2025中期报告

方達控股公司 * 股份代號 : 1521（於開曼群島註冊成立的有限公司） 目錄 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27. . . . . . . . . . . . . . . . . . . . . . . . . . . .49. . . . . . . . . . . . . . . . . . . . . . . .51. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .52. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .54. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .56. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .57. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .96 Wells Fargo Bank, N.A. Morgan, Lewis & Bockius Wentao Zhang2025162025528Zhongping Lin2025162025528 Conyers Dill & Pearman Conyers Trust Company (Cayman) LimitedCricket Square, Hutchins DriveP.O. Box 2681Grand Cayman, KY1-1111Cayman Islands 2025528Zhuan Yin 700 Pennsylvania DriveExton, PA 19341, USA 700 Pennsylvania DriveExton, PA 19341, USA 33191920 Conyers Trust Company (Cayman) LimitedCricket Square, Hutchins DriveP.O. Box 2681Grand Cayman, KY1-1111Cayman Islands 2025630Zhuan Yin2025630 1617 1521 www.frontagelab.com 2025546,300(CRDMO)(PBMC)DNA(FFPE)200,000CRDMO (25) 2024630128.51.5%2025630126.62025630404.72024630374.08.2% 20250.957.12025202520253.869.520247.8% 20251 2025546,300CRDMO(9)(GMP)(2)(2)(5)(2)(3) 2025 • 2025(R&D) (APP-PS1)(MRL/lpr)LNP • AlamarNULISAFujirebioLumipulseG1200 CRDMO20255 2025FDA(DEA)ISO/IEC 2025(NMPA) • mRNACAR-T GMP • mRNA NMPAFDA(GLP) 2025 2025630(14) •(4)•(2)•(1)•(1)•(1)•(1)•(1)•(1)•(1)•(1) 2025630(11) •(4)•(4)•(1)•(2) 2024855.42025922.7203221,755.3 2024630128.51.5%2025630126.6202463099.40.8%202563098.62024630206.529.12.7%2025630200.928.0 202557.1202569.5202464.57.8% 202553.4202545.218.1% 2025115.316.1202585.611.934.7% 202463019.11.6%202563018.8202563014.8%202463014.9% 202463027.01.9%202563027.5202563021.7%202463021.0% 202463093.62.5%202563091.3 202463034.81.4%202563035.3202463027.1%202563027.9% 202463029.4%202563030.4%202563019.2%202463019.3% 20246304.78.5%20256304.3 202463024.515.1%202563020.8202463018.212.1%202563016.0 (i)(ii) 20246302.821.4%20256302.2 20246304.32.3%20256304.2 20246300.720256302.2 20256302.920246300.320256302.3%20246300.2%2024630 20253.820250.9 20246306.126.2%20256307.720256306.1%20246304.8%2025630 20256.120251.6 3202463023.713.9%202563027.0202563021.4%202463018.4% 4202463025.88.9%202563028.1202463020.1%202563022.2% 20256300.001420246300.000120256300.001420246300.0001 20256300.003820246300.003122.6%20256300.003820246300.0031 202563051.62024123154.35.0% 202563026.62024123130.011.3% 2024123169.16.8%202563073.8 2024123118.911.1%202563021.0 2024123119.39.3%202563021.1 6.3% 202563033.72024123144.1 20256303.7202463016.477.4% 202563078.62024123195.720256302.60%6.45%51.3195.527.3 202563058.22024123158.7 2025630 100%20256302024123130.2%33.0% 20256301,5408357051,26627484%521 202563052.9202463058.5 20182021 2025630 20256302024630 2025630 20256302025630 2025630 2025630 13.51B(1)20241231 •Wentao Zhang2025162025528•Zhongping Lin2025162025528•2025528•Zhuan Yin2025630•2025630•2025519603014 3.21 2025630XV(a)XV78(b)352(c) (1)202563040,733,050TheLinna Li GST Exempt TrustThe Wendy Li GST Exempt TrustThe Yue Monica Li GST Exempt Trust202563045,600,09045,602,09045,606,090(2)Zhongping Lin2025162025528(3)Wentao Zhang2025162025528(4)Abdul Mutlib202516(5)2025528(6)20256302,035,724,910 2025630XVXV78352 2025630XV23336 (1)1,088,484,090226,020,000 (2)20256302,035,724,910 2025630XV23336 FrontageLabsFrontageLabsFrontage Labs20082015FrontageLabs9,434,43412,000,000FrontageLabs510 2018417Frontage LabsFrontageLabs201812314,035,000 201922820157,990,0002.00 201951110% (1)(2)Zhongping Lin2025162025528(3)Abdul Mutlib202516 0.0490.057 202120155,001,0002025630 2019228 201922818%3% 20256302024630 2018 201951120182018 (i)2018 20182018 2018 (ii) 201820182018 (iii)2018 2018200,764,09110% 201885,823,5914.2% (iv) 121% 2018 (v) 201810 (vi) 2018 (vii) 1.00 2018 (viii) a)b)c) 2018 (ix)2018 201820195301010 2025630 (ix)2018 (ix)2018 2018 (ix)2018 (1)2.06(2)2.16(3)0.73(4)(5)20271062028122020291030(6)Wentao Zhang2025162025528(7)Zhongping Lin2025162025528(8)Abdul Mutlib202516 20256302018201885,823,59185,823,591 2018202210720231220202410303,255,0002,988,0001,839,000 2018 (ix)2018 2022107 0.250.2752.0%53.7%– 20231220 0.270.2751.0%53.0%– 0.110.1164.0%53.0%– 2018 (ix)2018 5 202563020181,045,00020246301,182,000 2021 202112220212021 (i)2021 2021 (ii) 20212021(i)(ii)20212021 2021 (iii)2021 2021204,605,091202110% 2021181,654,5918.9% (iv) 20212021122(1%) (v) 2021 (vi)(vii) 2021 (viii)2021 202120211221017202311 2021125202118422,950,50022,950,500(i)19,850,500182(ii)3,100,0