君圣泰医药-B2024年度报告

年度報告 24621485571767778808183137144 於 於萌 D 24840 Cricket SquareHutchins DriveP.O. Box 2681Grand Cayman KY1-1111Cayman Islands 191001-1010 83One Bay East21 15434301-10 5025 829 201614 212101-2105 2511 www.hightidetx.com 183171712-1716 Conyers Trust Company (Cayman) LimitedP.O. Box 2681Grand Cayman KY1-1111Cayman Islands 君聖泰醫藥(HighTideTherapeutics,Inc.) 君聖泰醫藥(HTD1801)HTD1801HTD1801 HTD1801(T2DM)III2025NDAHTD1801T2DM(MASH)3T2DMIIIHTD1801T2DMT2DMHTD1801HTD1801(ADA)HTD1801T2DMIIHTD1801HTD1801(EASD)HTD1801T2DMIIHTD1801HTD1801T2DMIIJAMA Network OpenHTD1801T2DMIIIHTD1801 HTD1801MASHIIb2025GLP-1RAIIHTD1801MASHIIb(EASL)(AASLD)HTD1801MASHT2DMIIa HTD1801GLP-1RAHTD1801HTD1801HTD1801MASHT2DM 君聖泰醫藥+君聖泰醫藥DeepCureFirst-in-Class17 君聖泰醫藥HTD1801 君聖泰醫藥HTD1801 (HTD1801)-NMEAMPKNLRP3AMPKNLRP3HTD1801Lp(a)ApoBhsCRPALT/ASTHTD1801HTD1801 4,580HTD1801HTD18012HTD1801HTD4010HTF1037 HTF1057 HTD1804 HTD1805HTD2802 134HTD1801 7925 HTD1801 HTD1801-2 HTD1801•HTD18012III2IIb • •HTD18012IIaIIaHTD1801IIa •( A A S L D )M A S HI I aHTD18012HTD1801AASLD 1(GLP-1RA)HTD18012GLP-1RAHTD1801 HTD1801HTD1801 •HTD1801IIa •EASLIIaHTD1801GLP-1(GLP-1RAs)HTD1801HTD1801EASL GLP-1RAHTD18012GLP-1RAHTD1801 2HTD1801HTD1801HTD18012 HTD1801HTD1801 •IIb 2 •2222 •2IbIIHTD1801HTD1801HOMA-IR2Ib2II2IIaHTD1801 •JAMANetwork OpenHTD18012(T2DM)II12HTD18012 •60(EASD)2IIHTD18012HTD1801EASD 2HTD1801HTD18012 HTD18012 •84ADA2IIHTD18012HTD1801HTD180122 •HTD18012III(SYMPHONY-1SYMPHONY-2)•HTD18012III(HARMONY)III2HTD180124•SYMPHONYHARMONY•2(NDA) •HTD1801 •HTD1801HTD1801•HTD1801IIHTD1801HTD1801HTD1801HTD1801IIIII •omega-3•HTD1801200HTD1801HTD1801•IHTD1801HTD1801II HTD4010 •HTD1801HTD4010 •HTD4010IHTD4010Toll4(DDW)HTD4010 HTF1037 •HTF1037GLP-1HTF1037NASASTALT(ROS)HTF1037HTF1037 HTF1057 •HTF1057HTF1057HTF1057(BDNF) HTD1804 •HTD18042 •HTD18042HTD1804 HTD1805 •HTD1805HTD1805HTD1801HTD1805 HTD2802 •HTD2802HTD2802 HTD1801HTD18012(NDA)2HTD18012 (i)(ii)(iii)(iv)(v) 34.233.868.098.8%28.5 522.2 2.63.26.13.1 (i)(ii)(iii)(iv) 311.616.7%363.560.7 136.740.6%81.2 1.5400,0000.7 381.8939.3 513.4310.8202.6608.248.9%310.8 109.951.546.96.05.5 56.93.53.2%3.7% (1)(2) (1)(2) Apollo Multi-Asset Growth FundChaince Capital Fund LP12.5Apollo Multi-Asset Growth FundChaince Capital Fund LP130.549.323.3%8.8%11.2 4.30.8(i)(ii)(iii) 2.6 70 108.2116.3 D. 8 於萌 6225 1 706648.655.6 401(k) 5%1,500 HTD1801HTD1801HTD1801HTD1801HTD1801 2.4 24A HTD1801 (i)HTD180150.0(ii)50.0(iii)HTD180130.0(iv)30.0 62.90% HTD1801(i)(ii)HTD1801HTD1801(a)HTD1801(b)(c)HTD1801 HTD1801HTD1801 HTD1801 =25%× (a)(b)(c)(d)(e)(f) (d)(e) HTD1801HTD1801 5%HTD1801A HTD1801HTD1801HTD1801 (4)HTD180114A.5514A.56 14A.52HTD1801 (5)HTD1801HTD1801HTD1801 1 4 A . 5 314A.53HTD1801 (6) HTD180114A.5214A.53 14A.53HTD1801 (1)HTD1801A (2)HTD1801(3)HTD1801 HTD180114A.5514A.56 14A.53HTD1801 24AA •••• 36.7%44. 5%12.5%19.2% 5% • 13.22 • 144 1 13.20 13 22 20 76136 194.1132.2 於萌 400,000600,000200,000 XV(a)XV78(b)352(c) (1)L(2)514,770,668(3)Founder BVI81,000,000(4)18,856,466(5)10,004,9645,775,094(6)FounderBVIZTGlobal EnergyFounderBVIZT Global Energy(i)(ii)ZTGlobal Energy6,369,3726,369,3728,917,1161.24%1.24%1.73% (7)AIH Capital L.P.AIH Capital L.P.80%(i)27,428,154(ii)2,766,000(8)5,926,5841,697,442(9)於萌6,032,5681,928,415(10)1,336,908856,605 XVXV78352 XV23336 (1)L(2)514,770,668(3)64,289,500HepalinkBiotechnology II LimitedHepalinkBiotechnology II LimitedHepalink Healthcare Partners I L.P.Hepalink Healthcare Partners I L.P.Hepalink HealthcarePartners I L.P.Hepalink Healthcare Partners I L.P.100%62.90%13,515,210Medi ProsperityCapital Inc.Hepalink Healthcare Partners I L.P.Medi Prosperity Capital Inc.Hepalink Healthcare Partners I L.P.(4)The Bryn Mawr Trust Company of DelawareFounder BVI(5)FounderBVIZT Global EnergyFounderBVIZTGlobal Energy(i)(ii)ZTGlobal Energy6,369,3726,369,3728,917,1161.24%1.24%1.73%(6)TCT (BVI) LimitedTCT (BVI) LimitedThe Core Trust Company Limited(7)60%40% 336 A. (c) (a) (b) (i)(ii)(iii) (d) (f) 53,095,764 25% (g) (e) 10 0.140.47 10% (i) (h) (10) (i)(ii)(iii) 424(d) 17.12 (1)17.07(1)(c)(v)(2)85,000(i)3,0001.23(ii)82,0001.0517.07(1)(d)1.0564(3)(4)25%(5)10(6)(i)(ii)(iii)(7)(8)17.07(1)(c)(iv) B. (a) (c) (b) (i)( i i )(iii) (d) (f) 9,600,000 25% (g) 0.33 (e) 10 (h) (i) (i)(ii) (i)(ii)(iii) 424(d)10% 17.12 C.17.07(3) 17.07(3) (i)(ii)(iii) 89 47,000 (HTD1801)2(T2DM)III 君聖泰醫藥 13.2013.2113.22 ••• 55 21(Hospitalfor Sick Children in Canada)CTLImmunoTherapies CorporationMannKindC o r p o r a t i o nAmericanType CultureCollectionStealthPeptide Inc.ABLEBioGroupLLC ••••AustraliaHighTide•HighTideTherapeutics,Ltd.•U.S.HighTide• •(Johns Hopkins University Carey Business School) 於萌43於萌 66 於萌CMC於萌於萌 ••0460••••688321• 於萌002821於萌 於萌於萌(Universityof Nevada,Reno) 50 ••• (i)(ii)(iii)(iv)(v) 45 1952SummitHealthcare AcquisitionCorporation (Universityof Connecticut)AmericanGraduate