艾美疫苗2024年中期报告

（於中華人民共和國註冊成立的股份有限公司） 股份代號： 中期報告2024 242 2 04 3 227 3 338 3 439 3 640 3 742 3 943 5 245 57 20248292024829 Ker Wei PEI Ker Wei PEI Ker Wei PEI ACGHKACG Ker Wei PEI20248292024829 97927 H 1617 1820 10564412 25 91A25 126 06660 3485 www.aimbio.com mRNAmRNAmRNA312,0008VeroVeroAC YW135(MPSV4)22 202463014211323 202413(PCV13) III 23(PPSV23)III 5mRNA RSVmRNA20(PCV20)b(Hib)2CDEMDCK CDEmRNARSVmRNAFDAmRNA RSVmRNA + 2024Vero VeroACYW135(MPSV4) 630537.220230.6% 1422914 13(PCV13) III 23(PPSV23)III AC YW135(MCV4) IIEV71-CA16 mRNA RSVmRNA20(PCV20)b(Hib)MDCKmRNARSVmRNAFDA 863580% (CHO)20325 203090%65%20222024 10μg/0.5ml20μg/0.5ml10μg20μg16160.5ml20ug0.5ml100% Vero Vero2007920086GMP 2007Vero16100%mRNA (HAV)HAV115320Eu/0.5ml15640Eu/1.0ml2024 AC Y W135(MPSV4) 20203MPSV4MPSV4AC YW135201810MPSV4201812GMPMPSV4MPSV4MPSV4(MCV4)II Vero Vero2007920082GMPVeroVero 820041020051GMP5000 (1)13(2)23III(3)20(4)24 PCV1367120246PCV13III2024 PCV132024630PCV13III3,78071 136620302001325.9%80% 131.813 GMP1323III III2024 Vero mRNAmRNAmRNA mRNA mRNAmRNA mRNARSVmRNAmRNAGSKRSV20235202324.6GSK202343.7mRNAFDAmRNA mRNA AC YW135(MCV4) (MPSV)122MCV4MCV4MCV2MCV4MCV4ACYW1353II EV71-CA16 71(EV71)A16(CA16)CA16CA16EV71-CA16EV71-CA16EV71CA16 mRNAAImRNAAI (i)(ii)mRNAmRNAmRNAmRNA mRNAPCV13PCV20 MCV4 RSV202030EV71-CA16EV71SabinIPV3030 2024630GMP2024630 2024630 2021 2019121 mRNAmRNAmRNAmRNAmRNAmRNADNAmRNAFDA2018FDAmRNA252023mRNAFDA982022mRNA2FDAFDA2024221mRNA230mRNA127mRNAmRNA PCV13PPSV232018PCV1334.6%65.6%2022PCV1372.6%88.3%PCV132022107.522.7%2025240PCV13PCV20PCV24PCV 20195,88020217,85033.6%2030220203035.0%mRNA2030mRNA21.2% 2024630RSVRSVRSV2024531mRNARSVmRNAmRNA2030RSV154 mRNA20302390.1%2030200 2015202261719.4%203012.3%2,203mRNA 2024ACYW135(MPSV4) (2024-2026)13 VeroAC YW135(MPSV4) GMP1323III 2024 2024537.22023540.53.3 2024148.92023107.841.138.1% 2024388.32023432.644.310.3% 202472.3%202380.1%7.8% 202413.4202321.07.636.2%2024 2024170.12023398.5228.457.3%202413232023720238IIIIII3III 2024232.22023224.97.33.3% 2024124.22023115.78.57.4%20232024 20243.920233.70.2 202430.0202319.210.856.6% 202414.0202352.438.473.2%2024 2024145.32023257.4112.243.6%2024 2024630655.320231231736.481.111.0% 20246302,478.72,912.0433.220231231119.0314.21323202463030550.0 2024630488.120231231509.921.84.3% 20246301,094.1202312311,005.189.08.9% 2024119.520242023111.08.57.6%2024213202423IIIIII 20246301,960.6202312311,795.6165.09.2%2024 202463052.4%2023123146.2%6.2% 2024630(1)2024630250.520231231259.4(2)202463058.02023123159.0(3) 2024630 2024630 20246301,55720236301,5722024180.42023175.2 2024630 91.61202310232024630 (1)202312mRNA(2)20236PCV13PCV20PPSV23(3)20231 2024630 2024630 2024630XVXV78352 (1)(2)20246301,211,062,599718,888,888492,173,711H (3)2024630200,000,0001,326,800H99.99%200,000,00010,135,23523,254,765H (4)5,000,00098%20,000,0005,150,000H5,160,000H (5)25,000,00025,000,000H 2024630XV(i)XV7878(ii)352(iii) 2024630336XV235% (6)49%51%61.25%40,000,000H (7)51%49%90%40,000,000H (8)0396883.20%13,013,400H14,358,400H (9)60087325,000,000H 2024630XV23336 18 20201130202221620201130 (a) (b) (c)12,106,6661%1%2024630H (d)6.98 (e)2020113084 (f) 202411784743,351,000202411202463020246303,201,00020246300.26% (1)202312120241130(2) 20246300.26% 20201231186,958,000 12.4312.7413.482.606.98(%)43.64%-45.78%(%)–(%)3.02%-3.08%37 202363021,855,000 20246302024630 20246302322002022(a)2021(b)2023(a)(b)20232024630 13.2013.2113.22 2024630 C1C.2.1 2024630 2024630 13.51(2)13.51B(1) 13.51(2)13.51B 2024630Ker Wei PEIKerWei PEIKer Wei PEI2024630 20248292024829 D2 D240D2322023 39562024630343434 2410 34 2024829 2024630 2024630 2024630 1. 20111192020918202092310564412 2022106 2.1 20246303420231231 2024630433,211,00020231231118,963,00012 2024630255,000,000101,000,000 122024630 2024630 2.2 20231231 161177 20202022 (a)1616 (b)2020202212 2023202411 2024630 2.2 (c)77 3. 4. 4. 5. 6. 2024630 7. 25% 20221012202463015% 20211119202463015%2024630202463015% 20211210202463015%2024630202463015% 20211210202463015%2024630202463015% 20231212202463015%202225% 7. 202251720211115% 8. 20246302023630 9. 1,211,062,59920236301,211,062,599 2024630 9. 20242023630 10. 202463020231231250,538,000259,358,000 20246302023123179,452,00081,737,000 202463066,188,000202363072,123,000 2024630123,000202363091,00047,000202363080,000 11. 11. 12. 2024630 13. 14. 15. (a) 15. (b) (i)20246305,505,00020236305,315,00020246304,568,000202312319,137,0002023123110,493,000 (ii)2024630168,0002023630168,000 (iii)2024630132,0002023630138,000 (iv)2024630306,0002023630612,000 2024630 15. (i)2015100%20237428,697,000202463031,920,00028,697,0003,223,000 (d) 16. 202463020231231 17. 18. 2024829