华芢生物-B二零二五年年报
（於中華人民共和國註冊成立的股份有限公司） 股份代號: 2396 2025年報 1245718274767707576787981138 20261302026130 1911507 1911507 1002829 33191915 H 1617 97927 242 826 2396 huarenshengwu.com 2025PDGF20251222 PDGF 2013PDGFPDGFPDGFGMP2025Pro-101-1IIIIbPro-101-1IIIaPro-101-2II AI AI PDGF 2026330 PDGF 2012PDGF20251231PDGFPro-101-1Pro-101-2rhPDGF-BB 2013PDGFPDGFPDGFPDGFFDAPDGFPDGFPDGFDNAFDAPDGFDNAPDGFPDGF 20251231141Pro-101-1IIIa2027IIIa2Pro-101-2II2027IIPDGF(i)(ii)(iii)(iv)(v)(vi)(vii)(viii)(ix)(x)(xi)PDGF(i)(ii)(iii)(iv)mRNAASO4 Pro-101-1Pro-101-2PDGF20251231Pro-101-1IIbIIIaPro-101-2IIPDGFmRNA4TNBCASO20251231 Pro-101-1 Pro-101-120251231Pro-101-1Pro-101-1 IIIaPro-101-120226Pro 101-120235Pro-101-1IIaPro 101-1IIa202312Pro 101-1IIb20254IIb20251220262025122026IIIaIIIa13176202112FDAPro-101-1INDFDA351(a)Pro-101-1BLAFDAIIIIND2026PMDA Pro-101-2 Pro-101-2 20217Pro-101-2IND10I20222II202412II1602026331Pro-101-2II12780%20259 306843%II2026 Pro-101-22027FDAIIIIND2027PMDAIIICTN Pro-101-3202112Pro-101-2IPro-101-3Ib20223Pro-101-3IbPro-101-22025Pro-101-1IIaIIbPro-101-2IIND2026319 Pro-1022028IND Pro-103PDGF2026IND Pro-104PDGF202512312029IND Pro-105PDGFPDGFrhPDGF-BB2027IND mRNAASO PDGFmRNAMes-201ASOOli-101Oli-20120251231mRNAASO Pro-201 20251231T42026T42026Pre-IND PDGF 202589.417 6931 PDGFPDGF mRNALNP 202512312530 2025 •••• 2026 1. —Pro-101-1IIIaIIbFDAIIIINDPMDA—Pro-101-2II 2. —CMOGMP— 3. ——PDGFmRNAASO4 4. —Pro-101-1Pro-101-2 Pro-101-1 2027 —CMO/CDMOGMP—PDGF— 522,0002024261,000100.0%PDGF-BBPDGF-BB 41,000202420,000105.0%PDGF-BB 2024241,00099.6%2025481,000202492.3%202592.1%PDGF-BB (i)(ii) 20241.833.3%20252.4 2024116.81.5%2025118.6 (i)(ii)(iii)CDMOCRO(iv)(v)(vi)(vii) 202491.32.1%202589.4(i)202422025(ii)2025CDMOCRO 20246.080.0%20251.2 20240.21,250.0%20252.7 2024212.23.22025209.0 20241231125.6376.7%20251231598.7599.8 20251231635.90.62.9632.42025123137.29.13.424.7 202512 312.920243.5632.42024139.2 202512312024 20251231598.72024125.6635.92024142.737.2202417.117.120248.3 20251231 20251231 20251231 3.2202414.1 202512310.620240.8 202512311002024902025132.82024132.8 20201220211020242— C.— 3. 572012420244 271997120049200410201012 20076 3520201020244 Berkshire Hathaway Automotive2017420209 2023520193020244020183030202420254040 201482022 5620191020201220244 2819957200522005320075200782010820101120178201792019920198 199271995720027 682023720246 3319883199431994820215202511 198281987720091220161220162019 442023720244 172006820113201142016920161020189201942024720191220237202376008722021920255 200372006720111220179 472023620244 122011122013620136201892018920205202052024320243 20061220055 512024320244 212003420066200682014720148201910201911201980760 1997620081020008 622024320244 26198861994319943200182005116818601818200511202111201710202111201972021112022620086 20115201912202012 198571988720025200512 602024320244 199071999111999112003112003112006720068201092010102013220133201472001122025— 19907200462006920117 2008SG1862008—2008200811200920096 5920216 18200572017620057201212008320121200912201462011520146201292017420211020179 198871991619977 4120243 1620173200862012720141220172 20086 20243 20231020221020235HOWOW.D2Y 202010 —— 452026130 18SPQ Asia Capital Limited 2010StarMine 55202012 301993199519962007Eli Lilly (Asia) Co., Limited200772012121011 19937 4620215 182005102012320097201162012420171220184201932019420214 2000720057202212 48202010 152003120042600285200772009760359020121120171020133201530024242015122020122025112025 2007720126201912 20261302012 1513 20244202512Vistra Group 20 13.51B(1) 20251231 13.51B(1) PDGF Pro-101-1Pro-101-2PDGF20251231Pro-101-1IIbIIIaPro-101-2IIPDGFmRNA4TNBCASO 6225 20251231 202512 31 Pro-101-1IIaPro-101-1Pro-101-1IIbPPSFASPro-101-1 IIIaIIIb Pro-101-1IIbPDGF rhPDGF-BB14PDGFrhPDGF-BBPDGF 2025123129.5%11.3% 202512315% 2025 8 2025123113 202512312024 13.2013.2113.22 1 26 20251231 20262026622102026 2026202661620266222026622202620266222026 20262026615H1617 2025123125 2025123120251231 20251231 20251231 (i)(ii) 20251231 3.13 89 20244292025123120251231202512 31 20251231543 20251231XV(a)XV78(b)352(c) (1)20251231117,657,522(1) 34,635,377(ii)83,022,145H (2)19,540,93717,980,00017,475,00012,000,0002024416 20251231(a)XV78(b)352(c) 1818 20251231XVXV23336 (2)19,540,93717,980,00017,475,00012,000,0002024416(3)9,090,793(4)20201130 20251231XV23336 8.10(2) 14A 20251171,536202511202612311,121,280 1,121,280.00 16 14A 2022123040,000202311202512 3113,333.33 5%3,000,00014A.76(1)(c)14A 20251120261231 14A.9814A 20251231303014A 20251231 2025123113.21 202012202110202421717 202512318,000,0006.80%4,785,0004.07%20251231 202512311716 (a) (b) 121212 (c) (d) 2025123112,785,00010.87%17 (e) (i)(ii)(iii)(iv)(v)2025123117 Pro-101-1Pro-101-2H38.2017,648,800H17,648,800(i)1,765,000H(ii)15,883,800H20251222 674.2599.833.99 (1) 20251231 20251231 20251231 202621020251231 2025123120262026 2