增强集团股份有限公司-美国存托凭证招股说明书（2026年6月25日版）

This prospectus supplement supplements the prospectus dated May 13, 2026 (the “Prospectus”) filed by Enhanced Group Inc.(the “Company”), which forms a part of the Company’s Registration Statement on Form S‑1 (Registration No. 333‑295777). Thisprospectus supplement is being filed to update and supplement the information in the Prospectus with the information contained in theCompany’s Current Report on Form 8‑K filed with the Securities and Exchange Commission on June 15, 2026 (the “Current Reporton Form 8‑K”). Accordingly, we have attached the Company’s Current Report on Form 8‑K to this prospectus supplement. Capitalized Our Class A common stock is listed on The New York Stock Exchange (“NYSE”) under the symbol “ENHA”. On June 24, 2026,the last reported sales price of our Class A common stock on NYSE was $3.51 per share. This prospectus supplement should be read in conjunction with the Prospectus, including any amendments or supplements to it,which is to be delivered with this prospectus supplement. This prospectus supplement is qualified by reference to the Prospectus,including any amendments or supplements thereto, except to the extent that the information provided by this prospectus supplement This prospectus supplement is not complete without, and may not be delivered or used except in conjunction with, theProspectus, including any amendments or supplements to it. We are an “emerging growth company,” as that term is defined under the federal securities laws and, as such, are subjectto certain reduced public company reporting requirements. Investing in our securities involves a high degree of risk. You should review carefully the risks and uncertaintiesdescribed in the section titled “Risk Factors” beginning on page 7 of the Prospectus, and under similar headings in anyamendments or supplements to the Prospectus. Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved ofthese securities, or passed upon the accuracy or adequacy of this prospectus supplement. Any representation to the contrary isa criminal offense. The date of this prospectus supplement is June 25, 2026. If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period forcomplying with any new or revised financial accounting standards provided pursuant to Section13(a) of the Exchange Act.☐ Item 1.01Entry into a Material Definitive Agreement Securities Purchase Agreement On June 14, 2026, Enhanced Group Inc., a Texas corporation (the “Company”), entered into a securities purchase agreement(the “Purchase Agreement”) with the investors identified therein (each, an “Investor” and, together, the “Investors”), including both (i)Apeiron Investment Group Limited (“Apeiron”), the controlling shareholder of the Company, whose sole voting equityholder isChristian Angermayer, Chairman of the Board of Directors of the Company (the “Controlling Stockholder”), and (ii) MaximilianMartin, Chief Executive Officer of the Company and a member of the Board of Directors of the Company, pursuant to which theCompany agreed to issue and sell in a private placement (the “Private Placement”) (A) 12,853,468 shares (the “Shares”) of theCompany’s Class A common stock, par value $0.0001 per share (the “Common Stock”) and (B) accompanying warrants to purchase12,853,468 shares of Common Stock (the “Warrants,” and together with the Shares, the “Securities”). The Shares and the Warrantswill be issued separately. The combined purchase price per Share and accompanying Warrant is $3.89, which is the closing price pershare of the Common Stock on the New York Stock Exchange on June 12, 2026. The gross proceeds to the Company from the PrivatePlacement are expected to be approximately $50.0 million (excluding aggregate gross proceeds that may be received in the future uponthe cash exercise of the Warrants), before deducting placement agent fees and other offering expenses payable by the Company.The Private Placement is expected to close in three tranches, with approximately $25.0 million of the gross proceeds expected to closeon or about June 17, 2026 (the “First Closing”), approximately $11.75 million of the gross proceeds expected to close on or about June22, 2026 and the remaining approximately $13.25 million of the gross proceeds expected to close as soon as reasonably practicable The Warrants will be exercisable from the date of issuance and have a term expiring on the earlier of (i) the fifth (5th) anniversary ofthe original issue date and (ii) the Accelerated Expiration Date (as defined below). As defined in the Warrant, if the closing sale priceof the Common Stock equals or exceeds $20.00 (as adjusted for any stock dividend, stock split, stock combination or other similartransaction following the original issue date) for any 20 consecutive trading days (the last day of such 20 consecutive trading dayperiod, the “Accelerated Exercise Trigger Date”)