维亚生物2025年度报告

年度報告 24710304553719399101104106109241 Chartered Governance Institute 97927 榮 榮 榮 榮 PO Box 309Ugland HouseGrand Cayman, KY1-1104Cayman Islands Chartered Governance Institute 735 33191901 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands 1617 1873 www.vivabiotech.com CROBDCROAIAIAICROCDMOCDMOCROCDMO •1,729.4655.6269.3222.021.3%314.6335.36.6%CRO •CRO16,169247CRO1,8661,673XDCPROTACCRO15.8%11.0%CRO •AIFICNew TargetNovel MOANew ModalityAIAIAI •AIDD19673AICRO12.0%AIAIMNC •PPQPPQ20262027CDMO860400CMC •VBI931983.6150.5205.1AI+SBDD • AIBD(SBDD)AICROCDMO 維 亞 生 物 主 1,729.41,986.712.9% 655.6687.44.6% 269.3222.021.3% 335.3314.66.6% i. a)b) AIAIBDCROAIAICDMOCROCDMO 2,7861,729.4655.637.9%3.3CRO269.3222.021.3%314.6335.36.6%CRO CROAI CRO810.9848.64.7%357.1383.17.3%CROBDCROCROCROAICRO CRO1,86625.7%CRO84.5%1.3%15.5%27.7%BD 98,88516,1692,3452471,67313XDCPROTACCRO15.8%11.0%CRO BDMNCAIAIDD196CADD/AIDD73AICRO12.0%AIAIMNC AIFICNew TargetNovel MOANew ModalityAIAIAIEnchantment of DrugDiscoveryAIDDAIDDV-ScepterV-Orb V-Mantle(PDC)AI CDMOCMC CDMOPPQPPQCMC 880.8286.6FDACDMO 92068.0%100.0%CDMOPPQCDMO860400 CMCCMC295CMC96ArthrosiAR882(SOW)CMCBDCMCCMCBD45.0%55.0%CMCBD28.0%72.0%CMC 83.6205.1AI+SBDD9367.7%25.8% 13453.32311874419ArthrosiHayaMediarBasking Cybrexa FuseBioProviva 25.0 SBDDStructure-based Drug DiscoverySBDD(AI)SBDDNew TargetNovel MOANew ModalityAISBDD 2,345247PDBmRNA CROHDX-MSBioassay GPCRIonChannel ProteinsTransport Proteins 200XX-ray crystallography XRDNuclearMagnetic Resonance, NMRAIDEL AIV-DELDNADNADELAIGPCRASMS, SPRIntactBioassayASMSSPRHDX-MSX ADCADMEPK XDCXDCCADD/AIDDDELADCAOC APC PDC RDCXDCAI CADD/AIDDmRNAPCC AIAIDELAIPKPDCRDCAPCDEL4-12aa4-17aa5 AISBDDComputer-aided Drug Discovery, CADDArtificial Intelligence Drug Discovery, AIDD(modality)AIDDADME/PKPROTACRNA3D(NCAA)1/350%-70%AICADDAIDD AIAIAIEnchantment of Drug DiscoveryAIDDAIDDV-ScepterV-OrbV-Mantle(PDC)AI AISBDDCRO 2,169CRO1,123787 •40,000•7,5765,552•64,56415,00010,800•7,5455,305•6,3625,335 •(CADD)(AIDD) •40,9362,5002,513 (SBDD)AICROCDMO 1,729.41,986.712.9%CROCDMOCDMO(1)FDA(2)(3)CDMO 1,073.91,299.317.3%CRO 655.6687.44.6%37.9%34.6%CRO 46.581.743.0% 101.1112.29.9%CDMO 262.8251.94.3% 100.588.014.2% EFS5% 150.5Arthrosi Therapeutics, Inc.Fuse Biotherapeutics Inc.83.7 2.15.6 30.345.4 37.553.930.4% 48.773.733.9% 269.3222.0 335.3314.6CRO 1,088.8941.715.6% 2,128.21,088.81,411.2969.6672.9 44.4%45.9%607.3693.51,255.345.4969.6331.2 195.5185.622.6 85.8134.3 5% 5.416.2 2,156.42,156.4 Synthesis HKCDMOCROCDMOBD 榮 4552 1 6225 • CRO/CMO • EFSEFS • (i)(ii)(iii)(iv)(v)(vi) ISO 14001(PSCI)ES 2.4 30,016,0000.75% 40 14A 3002540%30%30%14A 14A 14A.71 33.8%33.8%25.6%26.8% 29.8%25.0%11.2%10.7% 5% 7 1 14 35 36 99240 1041052403,842.33,874.2 32 4,327,5005.4 (1) 1691731011 20621636 1617 64CRO29BVI • •ZRG1AARR-1 (50)•Medicilon Inc. 45 63CRO17Viva ManagementVivaGT 66CROCRO16 • • 10 54Fenghe Fund Management Pte. Ltd. 63Pharmacyclics,Inc. 榮53HK.3389HMIN(600258)MakeMyTrip LimitedMMYT6686NOAH 63 66MRK14 42 4610Scientific Leader & GSK FellowFrank and Sara McKnight FellowHelen Hay Whitney Fellow·50Faculty OpinionsSAPA-GP 53EHSNYSEBABACDN 39 51Vistra Corporate Services (HK) LimitedVistraVistra 25Chartered Governance Institute 13.2013.21 13.22 C.2.1 ••• 榮 4552 C.2.1 C.5.1 10C.5.1 3.13 3.21C.4D.3榮榮榮3.10(2)3.21 58 •••• 3.25E.1榮榮E.1.2(c)17 58 10 B.3榮 58 50596069 4548 55:45 40% A.2.1 C.1.4 C.1.1 榮 9398 • (1)(2)(3) •••••• Vistra Corporate Services(HK)Limited 3.2915 12.3 212150% 735201318+86 21 60893288+86 21 58243936info@vivabiotech.com www.vivabiotech.com XV(a)XV78(b)352(c) (1)L(2)Min Zhou 2018 Family TrustMZFT, LLCMZFT, LLCMin Zhou 2018 Family TrustThe Chen Mao Charitable Remainder TrustZhou MinZhou Min(3)維 亞 生 物 科 技 控 股 集 團(4)維 亞 生 物 科 技 控 股 集 團(5)HLC VGC Partners HK II LimitedHLC SPV85,000,000HLC SPVVGC Fund IV L.P.HLC VGC GP IV Limited(6)+ (ii) (1)(2)Chencheney Ltd.100.0%Chencheney Ltd.Anji PharmaceuticalsClues Therapeutics(3)Chencheney LtdClues Therapeutics Inc.447,039.0928%(4)(5)(6)5(7) XVXV78352 XV23336 (2)(3)Fenghe Harvest Ltd(3)JPMorgan Chase & Co.(4) 1.LS2.Mao and Sons LimitedZhang and Sons Limited JL and JSW Holding LimitedTIANL Holding Limited131,057,6543.Fenghe Harvest LtdWu and Sons Limited100.00%FengheHarvest LtdWu and Sons Limited4.29,500(S)5.Huangshan Investments Pte. Ltd.True Light Investments H Pte. Ltd.TemasekHoldings Private Limited+ XV23336 1. (a) (i)270,937,30257,892,3512,194,55522.07% (ii) (iii) (iv)(i)422(ii)(a)(b) (v) (vi)(i)(a)10%110%(b)100%(ii)85%(iii) (vii) (viii) (ix) (1)40%20%20%20% 2. 1 i.0.1% ii.5(i)(ii)(iii) i. ii.iii. 10%150,000,000 10% 30%30% 121% 121% (1)(i)40%(ii)30%(iii)30% 60%90%120%9.70 (2)(i)60%(ii)40%270%360%5.46 (3)(i)60%(ii)40% 90%2.89 (4)(i)40%(ii)30%(iii)30% 35%55%75%2.05 36118,085,000124,245