Lightwave Logic Inc美股招股说明书(2026-04-21版)

Up to $49,326,334 of Common Stock This prospectus supplement (“Prospectus Supplement No. 1”) amends and supplements the information in the prospectussupplement dated August 9, 2024 (the “Prospectus Supplement”) relating to the offer and sale of shares of our common stock, $0.001par value per share (“common stock”), pursuant to a sales agreement (as amended, the “Sales Agreement”) with Roth Capital Partners,LLC (“Roth Capital Partners”, or the “Sales Agent”). On April 20, 2026, we entered into an amendment to the Sales Agreement to increase the amount of shares of common stock thatmay be sold under the Sales Agreement to $51,404,500. Accordingly, as of the date of this Prospectus Supplement No. 1, shares of ourcommon stock having an aggregate offering price of up to $49,326,334 are available for offer and sale pursuant to the SalesAgreement, the Prospectus Supplement and this Prospectus Supplement No. 1, which we may offer and sell from time to time throughthe Sales Agent, acting as sales agent or principal. Since our entry into the Sales Agreement, we have offered and sold 8,079,319 shares of common stock for gross proceeds of This Prospectus Supplement No. 1 is not complete without and may only be delivered or utilized in connection with theProspectus Supplement, the accompanying base prospectus, and any future amendments or supplements thereto. Our common stock is listed on The Nasdaq Capital Market under the symbol “LWLG.” On April 17, 2026, the last reported saleprice for our common stock was $12.54 per share. Investingin our securities involves a high degree of risk. You should read the Prospectus Supplement and theaccompanying prospectus carefully before you make your investment decision. See “Risk Factors” beginning on page S-7 ofthe Prospectus Supplement, as well as the documents we file with the Securities and Exchange Commission that areincorporated by reference in the Prospectus Supplement and in the accompanying prospectus, including our most recentAnnual Report on Form 10-K and any subsequently filed Quarterly Reports on Form 10-Q and Current Reports on Form 8-K,for more information. Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved ofthese securities or determined if the Prospectus Supplement or the accompanying prospectus is truthful or complete. Anyrepresentation to the contrary is a criminal offense. Roth Capital Partners The date of this Prospectus Supplement No. 1 is April 20, 2026.