uniQure NV 2025年度报告

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.Yes☒No☐ Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities ExchangeAct of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject tosuch filing requirements for the past 90 days.Yes⌧No◻ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant toRule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required tosubmit such files).Yes☒No☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reportingcompany, or an emerging growth company. See the definitions of “large accelerated filer”, “accelerated filer”, “smaller reporting company” and“emerging growth company” in Rule 12b-2 of the Exchange Act. Accelerated filer☐Non-accelerated filer☐Smaller reporting company☐Emerging growth company☐ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of itsinternal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firmthat prepared or issued its audit report.☒ If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrantincluded in the filing reflect the correction of an error to previously issued financial statements.☐ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-basedcompensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b).☐ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act.)Yes☐No⌧ The aggregate market value of the voting and non-voting ordinary shares held by non-affiliates of the registrant, computed by reference to theclosing price on the Nasdaq Global Select Market as of the last business day of the registrant’s most recently completed second fiscal quarter, wasapproximately $764.8 million. As of February 26, 2026, the registrant had 62,529,408 ordinary shares, par value €0.05, outstanding. DOCUMENTS INCORPORATED BY REFERENCE Portions of the registrant’s definitive Proxy Statement for its 2026 Annual Meeting of Shareholders to be filed with the Securities andExchange Commission no later than April 30, 2026 and are herein incorporated by reference in Part III of this Annual Report on Form 10-K. TABLE OF CONTENTS PagePART ISPECIAL CAUTIONARY NOTICE REGARDING FORWARD-LOOKINGSTATEMENTS3Item1Business6Item1A Risk Factors40Item1B Unresolved Staff Comments88Item1C Cybersecurity88Item2Properties89Item3Legal Proceedings90Item4Mine Safety Disclosures90PART IIItem5Market for Registrant’s Common Equity, Related Stockholder Matters and IssuerPurchases of Equity Securities91Item6Reserved92Item7Management’s Discussion and Analysis of Financial Condition and Results ofOperations93Item7A Quantitative and Qualitative Disclosures About Market Risk112Item8Financial Statements and Supplementary Data114Item9Changes in and Disagreements With Accountants on Accounting and FinancialDisclosure114Item9A Controls and Procedures114Item9B Other Information116Item 9CDisclosure Regarding Foreign Jurisdictions that Prevent Inspections116PART IIIItem10 Directors, Executive Officers and Corporate Governance116Item11 Executive Compensation116Item12 Security Ownership of Certain Beneficial Owners and Management and RelatedStockholder Matters117Item13 Certain Relationships and Related Transactions, and Director Independence117Item14 Principal Accounting Fees and Services117PART IVItem15 Exhibits, Financial Statement Schedules118Item16 Form10-K Summary118 SPECIAL CAUTIONARY NOTICE REGARDING FORWARD-LOOKING STATEMENTS This Annual Report on Form10-K contains “forward-looking statements” within the meaning ofthe federal securities laws. Forward-looking statements are based on our current expectations of futureevents and many of these statements can be identified using terminology such as “believes,” “expects,”“anticipates,” “plans,” “may,” “will,” “projects,” “continues,” “estimates,” “potential,” “opportunity” andsimilar expressions. These forward-looking statements involve known and unknown risks, uncertaintiesand other factors that may cause our actual results, levels of activity, performance or achievements to bematerially different from the information expressed or implied by these forward-looking statements. Theseforward-looking statements include, without limitatio