百时美施贵宝 2024年度报告

FORM 10-K ___________________________ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THESECURITIES EXCHANGE ACT OF 1934For the fiscal year ended December 31, 2024ORTRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THESECURITIES EXCHANGE ACT OF 1934For the transition period from ______ to _______Commission File Number 001-01136___________________________ (Exact name of registrant as specified in its charter)___________________________ Delaware (State or other jurisdiction ofincorporation or organization)(I.R.SEmployerIdentification No.)Route 206 & Province Line Road, Princeton, New Jersey 08543(Address of principal executive offices)(609) 252-4621(Registrant’s telephone number, including area code)Securities registered pursuant to Section 12(b) of the Act: Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 orSection 15(d) of the Act.YesNo Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter periodthat the registrant was required to file such reports), and (2) has been subject to such filing requirements forthe past 90 days.YesNo Indicate by check mark whether the registrant has submitted electronically every Interactive Data Filerequired to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during thepreceding12 months(or for such shorter period that the registrant was required to submit suchfiles).YesNo Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule12b-2 of the Exchange Act. If an emerging growth company, indicate by check mark if the registrant has elected not to use theextended transition period for complying with any new or revised financial accounting standards providedpursuant to Section 13(a) of the Exchange Act. Indicate by check mark whether the registrant has filed a report on and attestation to its management’sassessment of the effectiveness of its internal control over financial reporting under Section 404(b) of theSarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued itsaudit report. If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether thefinancial statements of the registrant included in the filing reflect the correction of an error to previouslyissued financial statements. Indicate by check mark whether any of those error corrections are restatements that required arecovery analysis of incentive-based compensation received by any of the registrant's executive officersduring the relevant recovery period pursuant to §240.10D-1(b). Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of theExchange Act).YesNo The aggregate market value of the 2,026,400,768 shares of voting common equity held by non-affiliatesof the registrant, computed by reference to the closing price as reported on the New York Stock Exchange,asof the last business day of the registrant’s most recently completed second fiscal quarter wasapproximately$84,156,423,913.Bristol-Myers Squibb Company has no non-voting common equity.AtFebruary 6, 2025, there were 2,029,312,023 shares of common stock outstanding. DOCUMENTS INCORPORATED BY REFERENCE: Portions of the definitive proxy statement for theregistrant’sAnnual Meeting of Shareholders to be filed within 120 days after the conclusion of theregistrant'sfiscal year ended December 31,2024 with the U.S.Securities and Exchange Commissionpursuant to Regulation 14A of the Securities Exchange Act of 1934, as amended, are incorporated byreference into Part III of this Annual Report on Form 10-K to the extent described therein. BRISTOL-MYERS SQUIBB COMPANYINDEX TO FORM 10-KDecember 31, 2024 PART I Item 1.Business1Acquisitions, Divestitures, Licensing and Other Arrangements2Products, Intellectual Property and Product Exclusivity2Research and Development8Alliances14Marketing, Distribution and Customers14Competition15Pricing, Price Constraints and Market Access16 Government Regulation17Sources and Availability of Raw Materials20Manufacturing and Quality Assurance20Environmental Regulation21Human Capital Management and Resources21Foreign Operations22Bristol Myers Squibb Website22Item 1A.Risk Factors24Item 1B.Unresolved Staff Comments35Item 1C.Cybersecurity35Item 2.Properties36Item 3.Legal Proceedings36Item 4.Mine Safety Disclosures36 Information about our Executive Officers37 PART IA Item 5.Market for the Registrant's Common Equity, Related Stockholder Matters andIssuer Purchases of Equity Securities38Item 6.[Reserved]39Item 7.Management's Discussi