东曜药业-B2024年中期报告

2 3 17 21 22 24 25 26 40 53 1617 3485 120 www.totbiopharm.com.cn 1875 ESG • ADCCDMOADCCDMOCDMO® 2024CDMOCDMO 20246 30 1 •520,60359%400,40044%®CDMO/CMO113,791144%202427,801 CDMO 20223TAB014(wAMD)TAB014(MAH)202310TAB01420239 16TAB014 •CDMO31,559 •CDMO20ADC 171152pre-BLA8CDMO1.84104% CDMO®2024 18A.05 202449%20246303117 2 ® ®20212024630®Avastin®1002030490202120307.6%2030184202120308.3%®2022® ® ®2021531NMPA2021®20222024630 2.ADC (ADC) 1. –ADC ADCADCDS-8201HER2ADC30.0%2022792030647 20214,10020257,10214.7%2030ADCADC2024(ASCO)ADC 2023ADC10015ADC5202310ADCADC1,000ADC15370ADCCDMOADC(XDC)(XDC)XXDC ADC CDMOADC ADCCMCADCCDMO70%34% ADC CDMO2022152018202234.5%21.8%2030ADC CDMO1102022203028.4%ADCADC CDMO CDMO 2.CDMO –2.1•ADC 1.CDMO 202420246 30CDMO/CMO113,791144%ADC88%2017ADC20246 308pre-BLA2 ··ADCADCCDMOXDCDNAIND15 100%200% ADC GMPGMP202463060GMPQPGMPGMP(DMS)(ERP)(EMS)VAISALA(LIMS) –2.2 ADCCDMO20237GL-DisacLink®ADCCDMOXDCGL-DisacLink®ADCCMC –2.3GMP NMPAFDAGMPICHQ10FDAALOCA+ CDMOGMP –2.4 422ADC54303,000ADC9605302023CDMOCDMOADCADCpre-BLACDMOADC CDMO 95%ADC90% –2.5CDMO CDMOCDMO15+CDMO20246 30CDMO29%49286%ADC CDMO27%ADC84% –2.6 CDMOpre-BLA 2024CDMOADC/XDC/AXCCDMOCDMO 1 GMPADCCDMO20,000LADC100L500L5kg6,000~50,000GMPADC ADC •20244XDCXDCAb/ADC/XDCCDMOADC 2024 •202422024ADCADCADCADC •20246BiG&ADCADCCDMO •20243ADCVSVSCDMOCDMOXDC CDMOADC CDMO 2024ADCASCO100ADC CDMOCDMO 2024520,6032023328,063192,54059%202431,559202315,163202446,059202349,969202432,105202331,1042024276,4822023197,376 CDMO 202446,059202349,9693,910 2024276,4822023197,37679,106CDMO CDMO/CMO 2024400,4002023277,881122,51944%® 2024CDMO/CMO113,791202346,54667,245144%CDMO/CMO 202432,105202331,1041,001 202420231 20249,45120234808,971 202431,559202315,163 2024630723,8872023686,68637,201 20241,545202313,39011,845 20246 30348,3502023351,6003,250 20242,18220231,278904 202427,801202362,41334,612CDMO68,784202384,74815,96436,209202334,0852,124 20243,88120232,2611,620 2024630383,008202312 31344,285323,892202312 31265,71514 2024 20246 30 20246 300.52023 12 310.5 20246 30 202111 91.8202112 3183,500202112 3120246 308,35031,316 2021ADC20246 309,602 20246 30 20246 3057220246 30 (1) 202496,742202380,899 1 200912 43485 CDMOCMO 201911 8 20248 13 2 2.1 20246 3034 202312 31 20246 30202312 31622436 622662(3)63202312 31 2 2.1 (a) (b) 3 3.1 20231231 202312 31 3.2 3 3.3 13 1 22 33 20246 30202312 31 • • 20246 3020236 30 20246 3012 320236 30 4 2023 5 (a) CDMO/CMO (b) 5 (d) (e) 2017110 84,500,00020246 3055,500,00020246 30202363029,000,000 2022110 30,000,00020246 3025,000,00020246 3020236 305,000,000 CDMO/CMO115 5 (f) 202420236 30 6 i2021202362,100,00013,873,00018,053,0004,033,000202312 317,185,0002,150,000 20246 3020246 309,335,000 7 8 9 (a) (b) 20246 3020236 300.04 12 (a) 20246 30202312 31 12 13 20246 30202312 3147,590,948 14 16 20246 30202312 31 17 (a) 18 202420236 3020246 30202312 31 (a) 202312 30 (b) (i) 20246 30XVXV78352 (1)L(2)20246 30772,787,887(3)(4)Teeroy Limited 20246 30XV78352 20246 30XV23336 (1)L (2)20246 30772,787,887 (3)Advantech Capital Investment V Limited49,136,800Advantech CapitalInvestment V LimitedAdvantech Capital II Master Investment LimitedAdvantech Capital II L.P.Advantech Capital II L.P.Advantech Capital II L.P.Advantech Capital Partners II LimitedAdvantech Capital Partners II LimitedAdvantech Capital II Master Investment LimitedAdvantech Capital II L.P.Advantech Capital Partners IILimitedAdvantech Capital Investment V Limited (4)Chengwei Evergreen Capital, L.P.56,573,500Chengwei Evergreen Capital, L.P.Chengwei Evergreen Capital, L.P.Chengwei Evergreen Management, LLCChengwei Evergreen Management, LLCChengwei Evergreen Capital, L.P. (5)Vivo Capital Fund VIII, L.P.90,718,100Vivo Capital Surplus Fund VIII, L.P.12,526,900Vivo Capital Fund VIII, L.P.Vivo Capital Surplus Fund VIII, L.P.Vivo CapitalVivo CapitalVivo Capital VIII, LLCVivo Capital LLCVivo CapitalVivo Capital VIII, LLCVivo Capital VIII, LLCVivo Capital LLCVivo Capital (6)116,250,000 (7)Tricor Trust (Hong Kong) Limited202020205 2938,993,566 20246 30XV23336 20132 20201712 11201812 2020193 1220194 1620197 22 V-36V-47202326 20246 30 (1)(i)(ii)(iii)1.0020143 30.286V-37V-38 (2)20223 1 7,819,6001.01% 13,700,000202211187,558,390202212 307,558,390 2020 20205 292020(i)(ii)2020202020207 29202112 23202211 12020106 20246 3020205,274,9130.68%2023 12 315,274,9132020TricorTrust (Hong Kong) Limited13,141,5912023123112,141,59120227292020202420202024 202057,000,0005,700,00020202021202014,250,000202112232020202112 23(1)(2)(3) 202020208 382120211223(1)(2)(3)202211 1(1)(2)(3)(4)202212 8202326 2020529202020208431,413,7962020122830,466,697202112 232813,700,000202112 30 2020 20246 302020 (1) (2)(i)20205 29(ii)202112 23202211 1 12772,787(3)12772,787 2024 20245 292024(i)(ii)20202024626202420241010 20246 302024 202420245 301225 202477,2