The European heavy-duty vehicle manufacturers are committed to achieving carbon neutrality in road freight transport by 2050. By 2025, approximately 40,000 battery electric medium-duty and heavy-duty vehicles will be in operation in Europe, and this figure will increase to 270,000 by 2030. The first hydrogen fuel-cell electric vehicles are already being rolled out in Europe, and by mid-decade, the vehicle offerings will significantly increase, reaching at least 60,000 trucks in operation by 2030. However, the charging and refuelling infrastructure necessary for zero-emission heavy-duty vehicles is almost completely lacking. The review of the Alternative Fuels Infrastructure Directive (AFID) should set dedicated and binding infrastructure targets on European and member state levels. For battery electric heavy-duty vehicles, a target of 10,000-15,000 public and destination charging points should be set for no later than 2025, and a target of 40,000-50,000 charging points for no later than 2030. Additionally, a target of at least 40,000 lower power (100 kW) public overnight chargers at truck parking areas along the highways should be set for 2030. For hydrogen-powered heavy-duty vehicles, there should be a target of around 300 truck-suitable hydrogen refuelling stations by 2030.