This report discusses the challenges of organizing global R&D organizations and proposes eight imperatives to ensure a successful transformation across structure, governance, and process dimensions. The complexity of global R&D organizations poses an increasing management challenge as companies continue to grow through acquisition and expansion into new markets. R&D functions are expected to accelerate the pace of innovation while maintaining tight control of costs. To successfully optimize R&D’s contribution to business value, companies need to address these three key dimensions.