FORM 10-Q ☑Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the Quarterly Period Ended March 29, 2026☐Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Illumina, Inc.(Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation or organization) 5200 Illumina Way, San Diego, CA 92122(Address of principal executive offices) (Zip code) (858) 202-4500(Registrant’s telephone number, including area code)N/A(Former name, former address and former fiscal year, if changed since last report) Indicate by check mark whether the registrant (1)has filed all reports required to be filed by Section13 or 15(d) of the Securities Exchange Actof 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2)has been subject tosuch filing requirements for the past 90 days.Yes☑No☐ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant toRule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).Yes☑No☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reportingcompany, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and“emerging growth company” in Rule 12b-2 of the Exchange Act. Large acceleratedfilerAcceleratedfiler☐Non-accelerated filer☐Smallerreportingcompany☐Emerging growthcompany If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complyingwith any new or revised financial accounting standards provided pursuant to Section 13a of the Exchange Act.☐ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).Yes☐No As of April24, 2026, there were 151.3 million shares of the registrant’s common stock outstanding. ILLUMINA, INC.FORM 10-QFOR THE FISCAL QUARTER ENDED MARCH29, 2026TABLE OF CONTENTS CONDENSED CONSOLIDATED FINANCIAL STATEMENTS Condensed Consolidated Balance SheetsCondensed Consolidated Statements of OperationsCondensed Consolidated Statements of Comprehensive IncomeCondensed Consolidated Statementsof Stockholders’ EquityCondensed Consolidated Statements of Cash FlowsNotes to Condensed Consolidated Financial Statements1. Organization and Significant Accounting Policies2. Acquisitions, Intangible Assets and Goodwill3. Revenue4. Investments and Fair Value Measurements5. Debt6. Stockholders’ Equity7. Supplemental Balance Sheet Details8. Legal Proceedings9. Income Taxes10. Segment Information MANAGEMENT’S DISCUSSION & ANALYSIS Management’s Overview and OutlookResults of OperationsLiquidity and Capital ResourcesCritical Accounting Policies and EstimatesRecent Accounting PronouncementsQuantitative and Qualitative Disclosures About Market Risk Controls and ProceduresLegal ProceedingsRisk FactorsShare Repurchases and SalesAdoptions, Modifications or Terminations of Trading PlansExhibitsForm 10-Q Cross-Reference Index See “Form 10-Q Cross-Reference Index” within Other Key Information for a cross-reference to the parts and itemsrequirements of the Securities and Exchange Commission Quarterly Report on Form 10-Q. Consideration Regarding Forward-Looking Statements This Quarterly Report on Form 10-Q contains, and our officers and representatives may from time to time make, “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of1995.Words such as: “anticipate,” “intend,” “plan,” “goal,” “seek,” “believe,” “continue,” “project,” “estimate,” “expect,”“strategy,” “future,” “likely,” “may,” “potential,” “predict,” “should,” “will,” or similar words or phrases, or the negatives ofthese words, may identify forward-looking statements, but the absence of these words does not necessarily mean that astatement is not forward looking.Examples of forward-looking statements include, among others, statements we makeregarding: •our expectations as to our future financial performance, results of operations, or other operational results ormetrics;•the benefits that we expect will result from our business activities and certain transactions we have completed, ormay complete, such as product introductions, increased revenue, decreased expenses, and avoided expensesand expenditures;•our expectations of the effect on our financial condition of claims, litigation, contingent liabilities, andgovernmental investigations, proceedings, and regulations;•our strategies or expectations for product development, market position, financial results, and reserves;•our ability to successfully implement cost reduction plans i