UNITEDSTATES SECURITIESANDEXCHANGECOMMISSIONWASHINGTON,D.C.20549 FORM20-F REGISTRATIONSTATEMENTPURSUANTTOSECTION12(b)OR(g)OFTHESECURITIESEXCHANGEACTOF1934 OR ANNUALREPORTPURSUANTTOSECTION13OR15(d)OFTHESECURITIESEXCHANGEACTOF1934 ForthefiscalyearendedDecember31,2023OR TRANSITIONREPORTPURSUANTTOSECTION13OR15(d)OFTHESECURITIESEXCHANGEACTOF1934 OR SHELLCOMPANYREPORTPURSUANTTOSECTION13OR15(d)OFTHESECURITIESEXCHANGEACTOF1934 Dateofeventrequiringthisshellcompanyreport Forthetransitionperiodfromto Commissionfilenumber:001-38764 APTORUMGROUPLIMITED (ExactNameofRegistrantasSpecifiedinitsCharter) N/A (TranslationofRegistrant’sNameintoEnglish) CaymanIslands (JurisdictionofIncorporationorOrganization) IanHuen,ChiefExecutiveOfficerAptorumGroupLimited 17HanoverSquare,LondonW1S1BN,UnitedKingdomTel:+442080929299 Fax:+442039288277 (AddressofprincipalexecutiveofficesandName,Telephone,E-mailand/orFacsimilenumberandAddressofCompanyContactPerson) SecuritiesregisteredortoberegisteredpursuanttoSection12(b)oftheAct: TitleofEachClassTradingSymbol NameofEachExchangeonWhichRegistered ClassAOrdinaryshares,parAPMNASDAQCapitalMarket value$0.00001 SecuritiesregisteredortoberegisteredpursuanttoSection12(g)oftheAct: None(TitleofClass) SecuritiesforwhichthereisareportingobligationpursuanttoSection15(d)oftheAct: None(TitleofClass) Indicatethenumberofoutstandingsharesofeachoftheissuer’sclassesofcapitalorcommonstockasofthecloseoftheperiodcoveredbytheannualreport. ClassAOrdinaryShares:2,937,921ClassBOrdinaryShares:2,243,776 Indicatebycheckmarkiftheregistrantisawell-knownseasonedissuer,asdefinedinRule405oftheSecuritiesAct.Yes No Ifthisreportisanannualortransitionreport,indicatebycheckmarkiftheregistrantisnotrequiredtofilereportspursuanttoSection13or15(d)oftheSecuritiesExchangeActof1934.Yes No Indicatebycheckmarkwhethertheregistrant:(1)hasfiledallreportsrequiredtobefiledbySection13or15(d)oftheSecuritiesExchangeActof1934duringthepreceding12months(orforsuchshorterperiodthattheregistrantwasrequiredtofilesuchreports),and(2)hasbeensubjecttosuchfilingrequirementsforthepast90days.Yes No IndicatebycheckmarkwhethertheregistranthassubmittedelectronicallyeveryInteractiveDataFilerequiredtobesubmittedandpostedpursuanttoRule405ofRegulationS-Tduringthepreceding12months(orforsuchshorterperiodthattheregistrantwasrequiredtosubmitsuchfiles).Yes No Indicatebycheckmarkwhethertheregistrantisalargeacceleratedfiler,anacceleratedfiler,anon-acceleratedfiler,oranemerginggrowthcompany.Seedefinitionof“largeacceleratedfiler,”acceleratedfiler,”and“emerginggrowthcompany”inRule12b-2oftheExchangeAct. Largeacceleratedfiler Acceleratedfiler Non-acceleratedfiler Emerginggrowthcompany IfanemerginggrowthcompanythatpreparesitsfinancialstatementsinaccordancewithU.S.GAAP,indicatebycheckmarkiftheregistranthaselectednottousetheextendedtransitionperiodforcomplyingwithanyneworrevisedfinancialaccountingstandards+providedpursuanttoSection13(a)oftheExchangeAct. +Theterm“neworrevisedfinancialaccountingstandard”referstoanyupdateissuedbytheFinancialAccountingStandardsBoardtoitsAccountingStandardsCodificationafterApril5,2012. Indicatebycheckmarkwhethertheregistranthasfiledareportonandattestationtoitsmanagement’sassessmentoftheeffectivenessofitsinternalcontroloverfinancialreportingunderSection404(b)oftheSarbanes-OxleyAct(15 U.S.C.7262(b))bytheregisteredpublicaccountingfirmthatpreparedorissueditsauditreport. IfthesecuritiesareregisteredpursuanttoSection12(b)oftheAct,indicatebycheckmarkwhetherthefinancialstatementsoftheregistrantincludedinthefilingreflectthecorrectionofanerrortopreviouslyissuedfinancialstatements. Indicatebycheckmarkwhetheranyofthoseerrorcorrectionsarerestatementsthatrequiredarecoveryanalysisofincentive-basedcompensationreceivedbyanyoftheregistrant’sexecutiveofficersduringtherelevantrecoveryperiodpursuantto§240.10D-1(b). Indicatebycheckmarkwhichbasisofaccountingtheregistranthasusedtopreparethefinancialstatementsincludedinthisfiling: U.S.GAAP InternationalFinancialReportingStandardsasissuedbythe InternationalAccountingStandardsBoard Other *If“Other”hasbeencheckedinresponsetothepreviousquestion,indicatebycheckmarkwhichfinancialstatementitemtheregistranthaselectedtofollow.Item17 Item18 Ifthisisanannualreport,indicatebycheckmarkwhethertheregistrantisashellcompany(asdefinedinRule12b-2oftheExchangeAct).Yes No TABLEOFCONTENTS INTRODUCTIONii PARTI1 ITEM1.IDENTITYOFDIRECTORS,SENIORMANAGEMENTANDADVISERS1 ITEM4.INFORMATIONONTHECOMPANY57 ITEM2.OFFERSTATISTICSANDEXPECTEDTIMETABLE1 ITEM3.KEYINFORMATION1 ITEM5.OPERATINGANDFINANCIALREVIEWANDPROSPECTS97 ITEM4A. UNRESOLVEDSTAFFCOMMENTS 97 ITEM7.MAJORSHAREHOLDERSANDRELATEDPARTYTRANSACTIONS125 ITEM6.DIRECTORS,SENIORMANAGEMENTANDEMPLOYEES112 ITEM9.THEOFFERANDLISTING129 ITEM8.FINANCIALINFORMATION128 ITEM11.QUANTITATIVEANDQUALITATIVEDISCLOSURESABOUTMARKETRISK136 ITEM10.ADDITIONALINFORMATION129 ITEM12.DESCRIPTIONOFSECURITIESOTHERTHANEQUITYSECURITIES136 ITEM13.DEFAULTS,DIVIDENDARREARAGESANDDELINQUENCIES137 PARTII137 ITE