This brief examines the regional economic impacts of proposed health and human services cuts in California using input-output modeling software. The proposed cuts would have the greatest impact on job loss and state and local tax revenue reduction compared to other budget solutions. The Bay Area, Central Coast, Los Angeles, Northern/Sierra, Other Southern, Sacramento Area, and San Joaquin Area would all experience significant job losses and tax revenue reductions if the proposed cuts are implemented. The proposed cuts would also result in billions of dollars lost in federal matching dollars and general fund revenue. The specific programs that would be most affected include IHSS, Medi-Cal, Child Care, and CalWORKS.