The Cybersecurity Manufacturing Innovation Institute (CyManll) was established by the Department of Energy to enhance cybersecurity in energy-efficient manufacturing. The institute's focus is on conducting research and development to address evolving cybersecurity threats to manufacturing industries, and to share information and knowledge with the broader community of U.S. manufacturers. CyManll has several unique attributes that enable it to achieve its national objectives, including a sense of urgency, a strong partnership with the U.S. manufacturing industry, and an integrated technical approach. The institute's research topics are organized into research routes, which are designed to address specific impact goals. The roadmap provides an overview of the current state of U.S. manufacturing, as well as research themes and opportunities. The roadmap also includes a summary of manufacturing trends and sector profiles, and highlights the challenges facing the advanced manufacturing industry. The roadmap is intended for a wide audience, including policymakers, industry leaders, and researchers.