The report provides an outlook for U.S.-Mexico relations under the Biden administration. The authors argue that citizens' security should be a top priority, and a new chapter in security cooperation should be opened. Sustainable migration cooperation and a bilateral economic agenda for competitiveness and inclusive growth are also discussed. The report also touches on U.S.-Mexico energy relations, anti-corruption efforts, and the need for re-engagement on global and regional issues. The authors note that Mexico and the U.S. share a common destiny, and efforts to integrate their economies and societies have been matched by efforts to develop shared responsibility in various policy areas. The report concludes by discussing public opinion in Mexico and AMLO's rhetoric, as well as the need to fulfill North America's promise.