FORM 10-Q (Mark One) QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIESEXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2026OR TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THESECURITIES EXCHANGE ACT OF 1934 For the transition period from _____ to _____Commission File Number: 001-38841________________________________________________________ Precision BioSciences, Inc. (Exact Name of Registrant as Specified in its Charter)________________________________________________________ (I.R.S. EmployerIdentification No.) Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities ExchangeAct of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subjectto such filing requirements for the past 90 days.YesNo Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant toRule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required tosubmit such files).YesNo Table of Contents PageForward-Looking Statements3Risk Factor Summary5PART I.FINANCIAL INFORMATION7Item 1.Financial Statements (unaudited)7Condensed Balance Sheets7Condensed Statements of Operations8Condensed Statements of Changes in Stockholders’ Equity9Condensed Statements of Cash Flows10Notes to Condensed Financial Statements11Item 2.Management’s Discussion and Analysis of Financial Condition and Results of Operations22Item 3.Quantitative and Qualitative Disclosures About Market Risk31Item 4.Controls and Procedures31PART II.OTHER INFORMATION32Item 1.Legal Proceedings32Item 1A.Risk Factors32Item 2.Unregistered Sales of Equity Securities and Use of Proceeds86Item 3.Defaults Upon Senior Securities86Item 4.Mine Safety Disclosures86Item 5.Other Information86Item 6.Exhibits87Signatures88 FORWARD-LOOKING STATEMENTS This Quarterly Report on Form 10-Q contains forward-looking statements within the meaning of the Private Securities LitigationReform Act of 1995. We intend such forward-looking statements to be covered by the safe harbor provisions for forward-lookingstatements contained in Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of theSecurities Exchange Act of 1934, as amended (the “Exchange Act”). All statements other than statements of present and historicalfacts contained in this Quarterly Report on Form 10-Q, including, without limitation, statements regarding our future results ofoperations and financial position, business strategy and approach, including related results, prospective products, use and developmentof licensed products, planned preclinical studies and clinical trials, or discontinuance thereof, the status and results of our preclinicalstudies, expected release of interim data, expectations regarding the use and effects of ARCUS, including in connection within vivogenome editing, collaborations and potential new partnerships or alternative opportunities for our product candidates, potential newapplication filings and regulatory approvals, research and development costs, timing, expected results and likelihood of success, aswell as plans and objectives of management for future operations may be forward-looking statements. Without limiting the foregoing,in some cases, you can identify forward-looking statements by terms such as “aim,” “may,” “will,” “should,” “expect,” “exploring,”“plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential,” “seeks,” or“continue” or the negative of these terms or other similar expressions, although not all forward-looking statements contain thesewords. No forward-looking statement is a guarantee of future results, performance, or achievements, and one should avoid placingundue reliance on such statements. Forward-looking statements are based on our management’s beliefs and assumptions and on information currently available to us.Such beliefs and assumptions may or may not prove to be correct. Additionally, such forward-looking statements are subject to anumber of known and unknown risks, uncertainties and assumptions, and actual results may differ materially from those expressed orimplied in the forward-looking statements due to various factors, including, but not limited to, those identified in Part II. Item 1A.“Risk Factors” and Part I. Item 2. “Management’s Discussion and Analysis of Financial Condition and Results of Operations.” Theserisks and uncertainties include, but are not limited to: •our ability to become profitable;•our ability to procure sufficient funding to advance our programs;•risks associated with raising additional capital and requirements under our current debt instruments and effects of restrictionsthereunder;•our oper