德尼克斯投资美股招股说明书(2026-04-28版)

Filed Pursuant to Rule 424(b)(5)Registration Statement No. 333-289004 Supplement dated April 28, 2026To prospectus supplement dated January 27, 2026(To prospectus dated July 28, 2025) 67,354,187 shares Dynex Capital, Inc. This supplement (this “Supplement”) is being filed to update, amend and supplement certain information in the prospectus supplementdated and filed with the Securities and Exchange Commission (the “SEC”) on January 27, 2026 (the “Prospectus Supplement”) andthe base prospectus dated July 28, 2025 (the “Base Prospectus”), relating to the offer and sale, from time to time, of up to 67,354,187shares of our common stock, $0.01 par value (“common stock”), pursuant to that certain distribution agreement, dated June 29, 2018,as amended May 31, 2019, August 3, 2021, June 3, 2022, February 10, 2023, October 29, 2024, May 1, 2025, July 29, 2025, January27, 2026, and April 28, 2026 (collectively, the “Distribution Agreement”), with BTIG, LLC, Citizens JMP Securities, LLC, GoldmanSachs & Co. LLC (“Goldman Sachs”), JonesTrading Institutional Services LLC, J.P. Morgan Securities LLC, Keefe, Bruyette &Woods, Inc., Morgan Stanley & Co. LLC (“Morgan Stanley”), RBC Capital Markets, LLC, UBS Securities LLC, and Wells FargoSecurities, LLC (collectively, the “Sales Agents” and each individually, a “Sales Agent”). This Supplement should be read in On April 28, 2026, we entered into an amendment to the Distribution Agreement, pursuant to which Goldman Sachs and MorganStanley were added as Sales Agents under the Distribution Agreement, and accordingly, any reference to “Sales Agents” in the As of April 24, 2026, we have sold 170,922,998 shares of our common stock pursuant to the Distribution Agreement, leaving up to50,369,975 shares of our common stock available for issuance from and after the date hereof pursuant to the Prospectus Supplement Our common stock is listed on the New York Stock Exchange (the “NYSE”) under the symbol “DX.” The last reported sale price ofour common stock on the NYSE on April 27, 2026 was $13.79 per share. The validity of the securities offered pursuant to the Prospectus Supplement will be passed upon for us by Morrison & Foerster LLP.The Sales Agents are represented in this offering by Cooley LLP, New York, New York. Investing in our common stock involves certain risks. Before buying any shares, you should read the discussion of materialrisks of investing in our common stock under the caption “Risk Factors” beginning on page S-4 of the Prospectus Supplement,as well as those described in our most recent Annual Report on Form 10-K, any Quarterly Reports on Form 10-Q filed after Neither the SEC nor any state securities commission has approved or disapproved of these securities or passed upon theadequacy or accuracy of this Supplement, the Prospectus Supplement or the accompanying Base Prospectus. Any Goldman Sachs & Co. LLCKeefe, Bruyette & WoodsA Stifel Company