April 27, 2026 Dear Stockholders: Date:Wednesday, June 17, 2026 You are cordially invited to attend the 2026 annual meeting of stockholders of StandardBioTools Inc. (the ‘‘Annual Meeting’’) to be held exclusively online via live webcast onWednesday, June 17, 2026, at 11:30 a.m. Eastern Time. The meeting can be accessed by visitingat www.virtualshareholdermeeting.com/LAB2026, where you will be able to listen to themeeting live, submit questions, and vote online. We believe that a virtual stockholder meetingprovides greater access to those who may want to attend. This approach also aligns with ourbroader sustainability and cost-savings goals. Time:11:30 a.m. Eastern Time Details regarding the meeting, the business to be conducted at the meeting, and informationabout Standard BioTools Inc. that you should consider when you vote your shares are describedin the accompanying proxy statement. Place: Online atwww.virtualshareholdermeeting.com/LAB2026 At the Annual Meeting, three persons will be elected to our board of directors. In addition, wewill ask stockholders to: •approve, on an advisory basis, the compensation of our named executive officers asdisclosed in this proxy statement,•ratify the appointment of PricewaterhouseCoopers LLP as our independent registeredpublic accounting firm for our fiscal year ending December 31, 2026,•approve our 2026 Equity Incentive Plan, and•approve an amendment to our Amended and Restated 2017 Employee StockPurchase Plan to increase the number of shares of common stock available forissuance thereunder by 1,200,000 shares. Our board of directors recommends the approval of each of the proposals. Such other businesswill be transacted as may properly come before the Annual Meeting. Under Securities and Exchange Commission rules that allow companies to furnish proxy materials tostockholders over the Internet, we have elected to deliver our proxy materials to the majority of ourstockholders over the Internet. This delivery process allows us to provide stockholders with theinformation they need, while at the same time conserving natural resources and lowering the cost ofdelivery. On or about April 27, 2026 we intend to begin sending to our stockholders a Notice ofInternet Availability of Proxy Materials (the ‘‘Notice’’) containing instructions on how to access ourproxy statement for our Annual Meeting and our 2025 annual report to stockholders. The Notice alsoprovides instructions on how to vote online or by telephone, how to access the virtual AnnualMeeting, and how to receive a paper copy of the proxy materials by mail. We hope you will be able to attend the Annual Meeting. Whether or not you plan to attend theAnnual Meeting, we hope you will vote promptly. Information about voting methods is set forthin the accompanying proxy statement. Thank you for your continued support of Standard BioTools Inc. We look forward to seeing youat the Annual Meeting. Sincerely, Michael Egholm, Ph.D.President & Chief Executive Officer NOTE ABOUT FORWARD-LOOKING STATEMENTS This proxy statement and the accompanying materials contain forward-looking statements. All statements contained herein otherthan statements of historical fact, including statements regarding our future results of operations and financial position, our businessstrategy and plans, and our objectives for future operations, are forward-looking statements. The words ‘‘believe,’’ ‘‘could,’’ ‘‘seeks,’’‘‘may,’’ ‘‘plan,’’ ‘‘potential,’’ ‘‘predicts,’’ ‘‘projects,’’ ‘‘should,’’ ‘‘will,’’ ‘‘estimate,’’ ‘‘continue,’’ ‘‘anticipate,’’ ‘‘intend,’’ ‘‘expect,’’ and similarexpressions and the negatives of those terms are intended to identify forward-looking statements. Forward-looking statementsinclude information concerning our possible or assumed future cash flow, revenue, sources of revenue and results of operations,cost of product revenue and product margin, operating and other expense, potential royalty streams, business strategies, financingplans, expansion of our business, investments to expand our customer base, plans for our products, competitive position, industryenvironment, potential growth opportunities, market growth expectations, acceleration of growth, and potential merger andacquisition activity and restructuring plans. Forward-looking statements are subject to numerous risks and uncertainties that couldcause our actual results, performance, or achievements to be materially different from any future results, performance, orachievements expressed or implied by the forward-looking statements. Given these uncertainties, you should not place unduereliance on these forward-looking statements. Factors that could materially affect our future results, performance, or achievementsinclude but not limited to, risks that the anticipated benefits of our merger and acquisition activity or other commercialopportunities may otherwise not be fully realized or may take longer to realize than expected; risks that we may not realizeexpect