This white paper, developed by the IRENA Coalition's Working Group on Towards 100% Renewable Energy, highlights the opportunities and challenges faced by companies in the industrial sector that have set targets for 100% renewable electricity supply and meaningful targets for increasing the share of renewable energy in heating and cooling operations. The paper is based on case studies and interviews with companies, and showcases their experiences. The authors of the paper are Rainer Hinrichs-Rahlwes, David Renné, Charlotte Hornung, Namiz Musafer, Duncan Gibb, Chetna Hareesh Kumar, Aleksandra Mirowicz, Stephanie Weckend, Emma Åberg, Kelly Tai, and Anindya Bhagirath under the supervision of Rabia Ferroukhi from IRENA. The paper received valuable feedback and review from Constantinos Peonides (Alectris), Britta Schaffmeister (Dutch Marine Energy Centre), Steven Vanholme (EKOenergy), Rohit Sen (ICLEI – Local Governments for Sustainability), Roque Pedace (INFORSE), and Monica Olip.