The healthcare industry is undergoing a paradigm shift driven by new models of care, a shift from illness to wellness, and rising demand for personalized, long-term care. This shift is making innovation and transformation imperative for sustainability. Hospital information systems (HIS) play a crucial role in this paradigm shift, but they face challenges in driving digitization. The HIS solution space is changing with eight trends, and technology vendors are adapting their solutions and services to meet these needs. Arthur D. Little's analysis shows that healthcare providers are reorienting their investments in HIS and other core technologies.