康乃德生物医药2022年度报告

UNITEDSTATES SECURITIESANDEXCHANGECOMMISSION Washington,D.C.20549 FORM20-F ☐REGISTRATIONSTATEMENTPURSUANTTOSECTION12(b)OR (g)OFTHESECURITIESEXCHANGEACTOF1934 OR ☒ANNUALREPORTPURSUANTTOSECTION13OR15(d)OFTHESECURITIESEXCHANGEACTOF1934 ForthefiscalyearendedDecember31,2022OR ☐TRANSITIONREPORTPURSUANTTOSECTION13or15(d)OFTHESECURITIESEXCHANGEACTOF1934 OR ☐SHELLCOMPANYREPORTPURSUANTTOSECTION13OR15(d)OFTHESECURITIESEXCHANGEACTOF1934 Dateofeventrequiringthisshellcompanyreport:Notapplicable. Commissionfilenumber001-40212 ConnectBiopharmaHoldingsLimited (ExactnameofRegistrantasspecifiedinitscharter) Notapplicable (TranslationofRegistrant’snameintoEnglish) CaymanIslands (Jurisdictionofincorporationororganization)12265ElCaminoReal,Suite350 SanDiego,CA92130,USA(Addressofprincipalexecutiveoffices) Dr.ZhengWei 12265ElCaminoReal,Suite350SanDiego,CA92130,USATel:+1(858)727-1045 Fax:+1(858)614-7007 (Name,Telephone,Emailand/orFacsimilenumberandAddressofCompanyContactPerson)SecuritiesregisteredortoberegisteredpursuanttoSection12(b)oftheAct. Titleofeachclass TradingSymbol(s) Nameofeachexchangeonwhichregistered AmericanDepositaryShares,eachrepresentingoneOrdinaryShare, CNTBTheNasdaqGlobalMarket parvalue$0.000174perShare SecuritiesregisteredortoberegisteredpursuanttoSection12(g)oftheAct. None(TitleofClass) SecuritiesforwhichthereisareportingobligationpursuanttoSection15(d)oftheAct. None(TitleofClass) Indicatethenumberofoutstandingsharesofeachoftheissuer’sclassesofcapitalorcommonstockasofthecloseoftheperiodcoveredbytheannualreport. 55,041,247OrdinaryShares,parvalue$0.000174perShare Indicatebycheckmarkiftheregistrantisawell-knownseasonedissuer,asdefinedinRule405oftheSecuritiesAct.Yes☐No☒ Ifthisreportisanannualortransitionreport,indicatebycheckmarkiftheregistrantisnotrequiredtofilereportspursuanttoSection13or15(d)oftheSecuritiesExchangeActof1934.Yes☐No☒ Note–CheckingtheboxabovewillnotrelieveanyregistrantrequiredtofilereportspursuanttoSection13or15(d)oftheSecuritiesExchangeActof1934fromtheirobligationsunderthoseSections. Indicatebycheckmarkwhethertheregistrant(1)hasfiledallreportsrequiredtobefiledbySection13or15(d)oftheSecuritiesExchangeActof1934duringthepreceding12months(orforsuchshorterperiodthattheregistrantwasrequiredtofilesuchreports),and(2)hasbeensubjecttosuchfilingrequirementsforthepast90days.Yes☒No☐ IndicatebycheckmarkwhethertheregistranthassubmittedelectronicallyeveryInteractiveDataFilerequiredtobesubmittedpursuanttoRule405ofRegulationS-T(§232.405ofthischapter)duringthepreceding12months(orforsuchshorterperiodthattheregistrantwasrequiredtosubmitsuchfiles).Yes☒No☐ Indicatebycheckmarkwhethertheregistrantisalargeacceleratedfiler,anacceleratedfiler,anon-acceleratedfiler,oranemerginggrowthcompany.Seedefinitionsof“largeacceleratedfiler,”“acceleratedfiler,”and“emerginggrowthcompany”inRule12b-2oftheExchangeAct. LargeAcceleratedFiler ☐ AcceleratedFiler ☐ Non-AcceleratedFiler ☒ Emerginggrowthcompany ☒ IfanemerginggrowthcompanythatpreparesitsfinancialstatementsinaccordancewithU.S.GAAP,indicatebycheckmarkiftheregistranthaselectednottousetheextendedtransitionperiodforcomplyingwithanyneworrevisedfinancialaccountingstandards†providedpursuanttoSection13(a)oftheExchangeAct.☐ †Theterm“neworrevisedfinancialaccountingstandard”referstoanyupdateissuedbytheFinancialAccountingStandardsBoardtoitsAccountingStandardsCodificationafterApril5,2012. Indicatebycheckmarkwhethertheregistranthasfiledareportonandattestationtoitsmanagement’sassessmentoftheeffectivenessofitsinternalcontroloverfinancialreportingunderSection404(b)oftheSarbanes-OxleyAct(15U.S.C.7262(b))bytheregisteredpublicaccountingfirmthatpreparedorissueditsauditreport.☐ IfsecuritiesareregisteredpursuanttoSection12(b)oftheAct,indicatebycheckmarkwhetherthefinancialstatementsoftheregistrantincludedinthefilingreflectthecorrectionofanerrortopreviouslyissuedfinancialstatements.☐ Indicatebycheckmarkwhetheranyofthoseerrorcorrectionsarerestatementsthatrequiredarecoveryanalysisofincentive-basedcompensationreceivedbyanyoftheregistrant’sexecutiveofficersduringtherelevantrecoveryperiodpursuantto§240.10D-1(b).☐ Indicatebycheckmarkwhichbasisofaccountingtheregistranthasusedtopreparethefinancialstatementsincludedinthisfiling: U.S.GAAP☐InternationalFinancialReportingStandardsasissued bytheInternationalAccountingStandardsBoard☒ Other☐ If“Other”hasbeencheckedinresponsetothepreviousquestion,indicatebycheckmarkwhichfinancialstatementitemtheregistranthaselectedtofollow.Item17☐Item18☐ Ifthisisanannualreport,indicatebycheckmarkwhethertheregistrantisashellcompany(asdefinedinRule12b-2oftheExchangeAct).Yes☐No☒ TableofContents ABOUTTHISANNUALREPORT1 PRESENTATIONOFFINANCIALINFORMATION1 EXCHANGERATES1 CAUTIONARYSTATEMENTREGARDINGFORWARD-LOOKINGSTATEMENTS2 PARTI4 ITEM1.IDENTITYOFDIRECTORS,SENIORMANAGEMENTANDADVISORS.4 ITEM2.OFFERSTATISTICSANDEXPECTEDTIMETABLE.4 ITEM3.KEYINFORMATION.4 A.[Reserved]4 B.CapitalizationandIndebtedness4 C.ReasonsfortheOfferandUseofProceeds4 D.RiskFactors4 ITEM4.INFORMATIONONTHECOMPANY.76 A.Histor