The Manufacturing USA highlights report for November 2021 summarizes the accomplishments and impacts of the agency in 2020. The report emphasizes the importance of securing US global leadership in advanced manufacturing through large-scale public-private partnerships and ensuring American inventions are made in America. The report also highlights the development of advanced manufacturing technologies, empowering the advanced manufacturing workforce, building innovation ecosystems, and the achievements of various institutes under the Department of Commerce, Department of Defense, and Department of Energy. The report concludes with a new initiative, the Cybersecurity Manufacturing Innovation Institute.