This white paper by Capgemini provides an essential guide for manufacturing and CPG firms looking to move towards an autonomous supply chain. The study is based on interviews with 50 supply chain leaders in major enterprises across North America, U.K., and Europe. The key challenges faced by supply chain organizations, the suitability of current supply chain processes, the key benefits sought from and the characteristics of autonomous supply chains, the pattern of autonomous supply chain initiatives planned, the key technologies within a reimagined autonomous supply chain capability, the extent of vendor involvement and the key selection criteria in choosing a services partner to assist in autonomous supply chain adoption, and the challenges and key success factors in supply chain transformation are all discussed. The paper highlights the importance of digital transformation and the removal of manual processes in response to the pandemic's stress test on supply chains.